Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628 | 0.94 | LTB4R2 (0.54) | AGTR1LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL2629 | 0.94 | LTB4R2 (0.54) | AGTR1LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL1970 | 0.93 | LTB4R2 (0.51) | AGTR1LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL2033 | 0.84 | AGTR1 (0.66) | AGTR1LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL29561367 | 0.84 | AGTR1 (0.66) | AGTR1LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL2032 | 0.84 | AGTR1 (0.66) | AGTR1LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL1808771 | 0.84 | AGTR1 (0.66) | AGTR1LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL2319 | 0.83 | LTB4R2 (0.51) | AGTR1LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL2978 | 0.83 | AGTR1 (0.57) | AGTR1LTB4R2MMEFFAR1AKR1B1 | |
| SCHEMBL2979 | 0.83 | AGTR1 (0.57) | AGTR1LTB4R2MMEFFAR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |