SCHEMBL21810299

SCHEMBL21810299

CC(C)(C)OC(=O)NC1CCN(c2c(Br)cnc(Cl)c2C=O)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CKS1B P61024 1/20 0.46
▸ SKP1 P63208 1/20 0.46
▸ SKP2 Q13309 1/20 0.46
▸ JAK3 P52333 1/20 0.43
▸ BTK Q06187 1/20 0.43
▸ CNR1 P21554 1/20 0.40
▸ CNR2 P34972 1/20 0.40
▸ DRD2 P14416 3/20 0.39
▸ DRD3 P35462 1/20 0.38
▸ SUV39H2 Q9H5I1 5/20 0.38
▸ PDE10A Q9Y233 2/20 0.38
▸ CTSK P43235 2/20 0.38
▸ KMT2A Q03164 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ PIM1 P11309 1/20 0.37
▸ PIM3 Q86V86 1/20 0.37
▸ PIM2 Q9P1W9 1/20 0.37
▸ OPRM1 P35372 1/20 0.37
▸ OPRD1 P41143 1/20 0.37
▸ OPRK1 P41145 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20500351 0.89 CKS1B (0.47) CKS1BSKP1SKP2JAK3BTK
SCHEMBL20500375 0.88 CKS1B (0.46) CKS1BSKP1SKP2JAK3BTK
SCHEMBL23658236 0.87 CKS1B (0.46) CKS1BSKP1SKP2JAK3BTK
SCHEMBL20500497 0.86 CKS1B (0.45) CKS1BSKP1SKP2JAK3BTK
SCHEMBL21810232 0.86 CKS1B (0.45) CKS1BSKP1SKP2JAK3BTK
SCHEMBL20500374 0.84 CKS1B (0.43) CKS1BSKP1SKP2JAK3BTK
SCHEMBL20500373 0.81 CKS1B (0.49) CKS1BSKP1SKP2JAK3BTK
SCHEMBL30078465 0.81 CKS1B (0.49) CKS1BSKP1SKP2JAK3BTK
SCHEMBL21810255 0.80 CKS1B (0.42) CKS1BSKP1SKP2JAK3BTK
SCHEMBL30078473 0.80 TGM2 (0.46) CNR1CNR2CTSKKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4608808-A1 SOMATOSTATIN RECEPTOR 2 AGONISTS AND USES THEREOF Basecamp Bio Inc. (KY) 2025-09-03 — — EP disclosed
EP-4548974-A2 SOMATOSTATIN MODULATORS AND USES THEREOF Crinetics Pharmaceuticals, Inc. (US) 2025-05-07 — — EP disclosed
EP-3853218-B1 SOMATOSTATIN MODULATORS AND USES THEREOF CRINETICS PHARMACEUTICALS INC (US) 2025-02-19 — — EP disclosed
US-20240408247-A1 NON-PEPTIDE TARGETED THERAPEUTICS AND USES THEREOF RADIONETICS ONCOLOGY, INC. 2024-12-12 — — US disclosed
EP-4351653-A1 NON-PEPTIDE TARGETED THERAPEUTICS AND USES THEREOF Radionetics Oncology, Inc. (US) 2024-04-17 — — EP disclosed
US-11834462-B2 Somatostatin modulators and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2023-12-05 — — US disclosed
US-20230022513-A1 SOMATOSTATIN MODULATORS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2023-01-26 — — US disclosed
WO-2022261221-A1 NON-PEPTIDE TARGETED THERAPEUTICS AND USES THEREOF Crinetics Pharmaceuticals, Inc. (US) 2022-12-15 — — WO disclosed
US-20220048924-A1 SOMATOSTATIN MODULATORS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2022-02-17 — — US disclosed
US-11186590-B2 Somatostatin modulators and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2021-11-30 — — US disclosed
EP-3853218-A1 SOMATOSTATIN MODULATORS AND USES THEREOF Crinetics Pharmaceuticals, Inc. (US) 2021-07-28 — — EP disclosed
US-20200283453-A1 SOMATOSTATIN MODULATORS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2020-09-10 — — US disclosed
US-10696689-B2 Somatostatin modulators and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2020-06-30 — — US disclosed
WO-2020061046-A1 SOMATOSTATIN MODULATORS AND USES THEREOF Crinetics Pharmaceuticals, Inc. (US) 2020-03-26 — — WO disclosed
US-20200087318-A1 SOMATOSTATIN MODULATORS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2020-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230022513-A1 SOMATOSTATIN MODULATORS AND USES THEREOF SSTR5, SSTR2, SSTR4 CKS1B 3617/4885SKP1 4341/4885SKP2 4134/4885
US-20220048924-A1 SOMATOSTATIN MODULATORS AND USES THEREOF SSTR5, SSTR2, SSTR4 CKS1B 3617/4885SKP1 4341/4885SKP2 4134/4885
US-20200087318-A1 SOMATOSTATIN MODULATORS AND USES THEREOF SSTR5, SSTR2, SSTR4 CKS1B 3617/4885SKP1 4341/4885SKP2 4134/4885
US-20240408247-A1 NON-PEPTIDE TARGETED THERAPEUTICS AND USES THEREOF GRPR, SCTR, NPSR1 CKS1B 3431/4885SKP1 4418/4885SKP2 3479/4885
US-11834462-B2 Somatostatin modulators and uses thereof SSTR5, SSTR2, SSTR4 CKS1B 3617/4885SKP1 4341/4885SKP2 4134/4885
US-20200283453-A1 SOMATOSTATIN MODULATORS AND USES THEREOF SSTR5, SSTR2, SSTR4 CKS1B 3617/4885SKP1 4341/4885SKP2 4134/4885
US-11186590-B2 Somatostatin modulators and uses thereof SSTR5, SSTR2, SSTR4 CKS1B 3617/4885SKP1 4341/4885SKP2 4134/4885
US-10696689-B2 Somatostatin modulators and uses thereof SSTR5, SSTR2, SSTR4 CKS1B 3617/4885SKP1 4341/4885SKP2 4134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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