Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 13/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 12/20 | 0.47 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2181157 | 1.00 | PDE10A (0.47) | PDE10AMCHR1ADRA2ANAPEPLDHTR1A | |
| SCHEMBL2178481 | 0.87 | ALDH1A1 (0.45) | PDE10ANAPEPLDALDH1A1POLBHPGD | |
| SCHEMBL2178476 | 0.87 | ALDH1A1 (0.45) | PDE10ANAPEPLDALDH1A1POLBHPGD | |
| SCHEMBL2176953 | 0.87 | ALDH1A1 (0.47) | PDE10AALDH1A1POLBHPGDALOX12 | |
| SCHEMBL2176961 | 0.87 | ALDH1A1 (0.47) | PDE10AALDH1A1POLBHPGDALOX12 | |
| SCHEMBL2178021 | 0.85 | PDE10A (0.46) | PDE10ANAPEPLDALDH1A1POLBHPGD | |
| SCHEMBL2178013 | 0.85 | PDE10A (0.46) | PDE10ANAPEPLDALDH1A1POLBHPGD | |
| SCHEMBL12408685 | 0.80 | PDE10A (0.54) | PDE10AMCHR1NAPEPLDHSD11B1ALDH1A1 | |
| SCHEMBL12408672 | 0.80 | PDE10A (0.49) | PDE10AMCHR1ADRA2AALDH1A1POLB | |
| SCHEMBL2178921 | 0.80 | KDM4E (0.47) | PDE10AALDH1A1POLBHPGDALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342191-B1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORP (JP) | 2013-03-20 | — | — | EP | disclosed |
| US-20110166135-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166135-A1 | AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE | PDE10A, PDE3A, PDE3B | PDE10A 1/4885MCHR1 3825/4885ADRA2A 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.