Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.79 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.77 |
| ▸ | ROS1 | P08922 | 7/20 | 0.73 |
| ▸ | EGFR | P00533 | 3/20 | 0.73 |
| ▸ | INSR | P06213 | 2/20 | 0.73 |
| ▸ | IGF1R | P08069 | 2/20 | 0.73 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.73 |
| ▸ | PLK4 | O00444 | 1/20 | 0.73 |
| ▸ | STK25 | O00506 | 1/20 | 0.73 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.73 |
| ▸ | CASK | O14936 | 1/20 | 0.73 |
| ▸ | AURKA | O14965 | 1/20 | 0.73 |
| ▸ | GAK | O14976 | 1/20 | 0.73 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.73 |
| ▸ | MUSK | O15146 | 1/20 | 0.73 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.73 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.73 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.73 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21844685 | 0.91 | ALK (0.76) | ALKZAP70ROS1EGFRINSR | |
| SCHEMBL30165141 | 0.91 | ALK (0.76) | ALKZAP70ROS1EGFRINSR | |
| SCHEMBL18843559 | 0.91 | ALK (0.87) | ALKZAP70ROS1EGFRINSR | |
| SCHEMBL29316154 | 0.89 | ALK (0.81) | ALKZAP70ROS1EGFRINSR | |
| SCHEMBL13394910 | 0.89 | ALK (0.84) | ALKZAP70ROS1EGFRINSR | |
| SCHEMBL11916458 | 0.87 | ALK (0.80) | ALKZAP70ROS1EGFRINSR | |
| SCHEMBL22493385 | 0.87 | ALK (0.82) | ALKZAP70ROS1EGFRINSR | |
| SCHEMBL18843489 | 0.86 | ZAP70 (0.82) | ALKZAP70ROS1EGFRINSR | |
| SCHEMBL20805541 | 0.85 | ZAP70 (0.80) | ALKZAP70ROS1EGFRINSR | |
| SCHEMBL18334849 | 0.85 | ALK (0.93) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856192-A1 | DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF | Dana Farber Cancer Institute, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020069106-A1 | DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-02 | — | — | WO | disclosed |