Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.81 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.79 |
| ▸ | ROS1 | P08922 | 5/20 | 0.75 |
| ▸ | INSR | P06213 | 3/20 | 0.75 |
| ▸ | IGF1R | P08069 | 3/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.75 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.75 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.75 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.75 |
| ▸ | EGFR | P00533 | 2/20 | 0.75 |
| ▸ | MET | P08581 | 2/20 | 0.75 |
| ▸ | CDK4 | P11802 | 2/20 | 0.75 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.75 |
| ▸ | PLK4 | O00444 | 1/20 | 0.75 |
| ▸ | STK25 | O00506 | 1/20 | 0.75 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.75 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.75 |
| ▸ | CASK | O14936 | 1/20 | 0.75 |
| ▸ | AURKA | O14965 | 1/20 | 0.75 |
| ▸ | GAK | O14976 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24301100 | 0.94 | ALK (0.87) | ALKZAP70ROS1INSRIGF1R | |
| SCHEMBL18843559 | 0.92 | ALK (0.87) | ALKZAP70ROS1INSRIGF1R | |
| SCHEMBL13394910 | 0.90 | ALK (0.84) | ALKZAP70ROS1INSRIGF1R | |
| SCHEMBL21815096 | 0.89 | ALK (0.79) | ALKZAP70ROS1INSRIGF1R | |
| SCHEMBL11916458 | 0.88 | ALK (0.80) | ALKZAP70ROS1INSRIGF1R | |
| SCHEMBL30165141 | 0.88 | ALK (0.76) | ALKZAP70ROS1INSRIGF1R | |
| SCHEMBL21844685 | 0.88 | ALK (0.76) | ALKZAP70ROS1INSRIGF1R | |
| SCHEMBL20805541 | 0.88 | ZAP70 (0.80) | ALKZAP70ROS1INSRIGF1R | |
| SCHEMBL18843489 | 0.88 | ZAP70 (0.82) | ALKZAP70ROS1INSRIGF1R | |
| Tae-684 SCHEMBL282775 | 0.86 | ALK (1.00) | ALKZAP70ROS1INSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239787-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239787-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | BRIX1, TP53, XPOT | ALK 3935/4885ZAP70 3276/4885ROS1 1728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.