Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.76 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.73 |
| ▸ | EGFR | P00533 | 4/20 | 0.71 |
| ▸ | ROS1 | P08922 | 5/20 | 0.69 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.69 |
| ▸ | PLK4 | O00444 | 1/20 | 0.69 |
| ▸ | STK25 | O00506 | 1/20 | 0.69 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.69 |
| ▸ | CASK | O14936 | 1/20 | 0.69 |
| ▸ | AURKA | O14965 | 1/20 | 0.69 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.69 |
| ▸ | MUSK | O15146 | 1/20 | 0.69 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.69 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.69 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30165141 | 1.00 | ALK (0.76) | ALKZAP70EGFRROS1BMPR1B | |
| SCHEMBL21815096 | 0.91 | ALK (0.79) | ALKZAP70EGFRROS1BMPR1B | |
| SCHEMBL14866190 | 0.90 | ALK (0.73) | ALKZAP70EGFRROS1BMPR1B | |
| SCHEMBL28881275 | 0.88 | CCNK (0.77) | ALKCDK2AXLNEK2PTK2 | |
| SCHEMBL29316154 | 0.88 | ALK (0.81) | ALKZAP70EGFRROS1BMPR1B | |
| SCHEMBL18843559 | 0.88 | ALK (0.87) | ALKZAP70EGFRROS1BMPR1B | |
| SCHEMBL21847010 | 0.88 | ALK (0.81) | ALKEGFRINSRIGF1RCDK2 | |
| SCHEMBL19027382 | 0.87 | ALK (0.80) | ALKEGFRROS1ERBB2INSR | |
| SCHEMBL21847018 | 0.86 | EGFR (0.76) | ALKEGFRLRRK2 | |
| SCHEMBL16752955 | 0.86 | ALK (1.00) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220409731-A1 | DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-12-29 | — | — | US | disclosed |
| WO-2020069106-A1 | DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220409731-A1 | DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF | ALK, BCR, FAP | ALK 1/4885ZAP70 1262/4885EGFR 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.