Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | CTSB | P07858 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.58 |
| ▸ | BRD4 | O60885 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21816800 | 0.87 | MAPT (0.60) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL23715389 | 0.83 | KMT2A (0.59) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL10915347 | 0.82 | MAPT (0.61) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL9976072 | 0.82 | MEN1 (0.66) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL21816812 | 0.82 | MAPT (0.61) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL27853335 | 0.82 | MAPT (0.55) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL16879230 | 0.82 | KMT2A (0.60) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL9545607 | 0.82 | MAPT (0.58) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL28449760 | 0.82 | MAPT (0.57) | MAPTALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL23715706 | 0.81 | MAPT (0.53) | MAPTALDH1A1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12152048-B2 | Nitroxoline prodrug and use thereof | JIANGSU YAHONG MEDITECH CO., LTD. (CN) | 2024-11-26 | — | — | US | disclosed |
| CN-115697970-B | Preparation method of aromatic ether compound | 江苏亚虹医药科技股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-115427397-B | Crystal form of nitroquinoline prodrug, pharmaceutical composition containing crystal form, preparation method and application of pharmaceutical composition | 江苏亚虹医药科技股份有限公司 | 2024-01-26 | — | — | CN | disclosed |
| US-20230219928-A1 | PREPARATION METHOD FOR AROMATIC ETHER COMPOUND | ASIERIS PHARMACEUTICALS (SHANGHAI) CO., LTD. (CN) | 2023-07-13 | — | — | US | disclosed |
| US-20230219928-A1 | PREPARATION METHOD FOR AROMATIC ETHER COMPOUND | ASIERIS PHARMACEUTICALS (SHANGHAI) CO., LTD. (CN) | 2023-07-13 | — | — | US | disclosed |
| US-20230219928-A1 | PREPARATION METHOD FOR AROMATIC ETHER COMPOUND | ASIERIS PHARMACEUTICALS (SHANGHAI) CO., LTD. (CN) | 2023-07-13 | — | — | US | disclosed |
| EP-4177243-A1 | PREPARATION METHOD FOR AROMATIC ETHER COMPOUND | Jiangsu Yahong Meditech Co., Ltd. (CN) | 2023-05-10 | — | — | EP | disclosed |
| EP-4177243-A1 | PREPARATION METHOD FOR AROMATIC ETHER COMPOUND | Jiangsu Yahong Meditech Co., Ltd. (CN) | 2023-05-10 | — | — | EP | disclosed |
| CN-115697970-A | Process for producing aromatic ether compound | 江苏亚虹医药科技股份有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115427397-A | Crystal form of nitroxoline prodrug, pharmaceutical composition containing nitroxoline prodrug, and preparation method and application of nitroxoline prodrug | 江苏亚虹医药科技股份有限公司 | 2022-12-02 | — | — | CN | disclosed |
| WO-2021258979-A1 | PREPARATION METHOD FOR AROMATIC ETHER COMPOUND | 江苏亚虹医药科技股份有限公司 | 2021-12-30 | — | — | WO | disclosed |
| US-20210363165-A1 | NITROXOLINE PRODRUG AND USE THEREOF | JIANGSU YAHONG MEDITECH CO., LTD. (CN) | 2021-11-25 | — | — | US | disclosed |
| EP-3858814-A1 | NITROXOLINE PRODRUG AND USE THEREOF | Jiangsu Yahong Meditech Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |
| CN-111295372-B | Nitroxoline prodrugs and uses thereof | 江苏亚虹医药科技股份有限公司 | 2021-03-09 | — | — | CN | disclosed |
| CN-111646936-A | Process for producing aromatic ether compound | 江苏亚虹医药科技有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-111295372-A | Nitroxoline prodrugs and uses thereof | 江苏亚虹医药科技有限公司 | 2020-06-16 | — | — | CN | disclosed |
| WO-2020063824-A1 | NITROXOLINE PRODRUG AND USE THEREOF | 江苏亚虹医药科技有限公司 | 2020-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12152048-B2 | Nitroxoline prodrug and use thereof | NOS1, NOS2, NNT | MAPT 2243/4885ALDH1A1 706/4885KMT2A 2016/4885 |
| US-20230219928-A1 | PREPARATION METHOD FOR AROMATIC ETHER COMPOUND | F7, F5, CYP2F1 | MAPT 2697/4885ALDH1A1 883/4885KMT2A 1035/4885 |
| US-20210363165-A1 | NITROXOLINE PRODRUG AND USE THEREOF | NOS1, NOS2, NNT | MAPT 2243/4885ALDH1A1 706/4885KMT2A 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.