Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21820572 | 1.00 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AOPRK1HPGD | |
| SCHEMBL29832662 | 1.00 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AOPRK1HPGD | |
| SCHEMBL28573263 | 0.87 | ALDH1A1 (0.64) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL28573261 | 0.87 | ALDH1A1 (0.64) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL31520431 | 0.82 | MEN1 (0.37) | ALDH1A1MEN1KMT2AOPRK1HPGD | |
| SCHEMBL21820524 | 0.82 | NPC1 (0.45) | ALDH1A1OPRK1HPGDMAPTKDM4E | |
| SCHEMBL21820522 | 0.82 | NPC1 (0.45) | ALDH1A1OPRK1HPGDMAPTKDM4E | |
| SCHEMBL21820442 | 0.77 | HPGD (0.47) | ALDH1A1MEN1KMT2AOPRK1HPGD | |
| SCHEMBL21820443 | 0.77 | HPGD (0.47) | ALDH1A1MEN1KMT2AOPRK1HPGD | |
| SCHEMBL21808113 | 0.77 | HPGD (0.47) | ALDH1A1MEN1KMT2AOPRK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240101536-A1 | COMPOUNDS FOR TREATING CERTAIN LEUKEMIAS | TERNS PHARMACEUTICALS, INC. | 2024-03-28 | — | — | US | disclosed |
| US-10889571-B2 | Substituted benzoimidazoles and imidazo[4,5-c]pyridines for treating certain leukemias | Terns, Inc. (US) | 2021-01-12 | — | — | US | disclosed |
| US-20200087283-A1 | COMPOUNDS FOR TREATING CERTAIN LEUKEMIAS | Terns, Inc. (US) | 2020-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200087283-A1 | COMPOUNDS FOR TREATING CERTAIN LEUKEMIAS | ABL1, ABL2, BCR | ALDH1A1 1027/4885MEN1 4346/4885KMT2A 220/4885 |
| US-10889571-B2 | Substituted benzoimidazoles and imidazo[4,5-c]pyridines for treating certain leukemias | ABL1, ABL2, BCR | ALDH1A1 497/4885MEN1 4682/4885KMT2A 230/4885 |
| US-20240101536-A1 | COMPOUNDS FOR TREATING CERTAIN LEUKEMIAS | ABL1, ABL2, BCR | ALDH1A1 1027/4885MEN1 4346/4885KMT2A 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.