Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 4/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916145 | 0.88 | PTGS2 (0.45) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL5846200 | 0.86 | PTGS2 (0.54) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL8960142 | 0.86 | PTGS2 (0.54) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| Hydrochloric Acid SCHEMBL5846495 | 0.84 | PTGS2 (0.53) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL24628718 | 0.81 | PTGS2 (0.40) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL29415828 | 0.79 | PTGS2 (0.41) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL1500630 | 0.79 | PTGS2 (0.41) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL135272 | 0.79 | APP (0.45) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL19707538 | 0.75 | GABRA1 (0.37) | ALDH1A1MAPK1 | |
| SCHEMBL2183207 | 0.75 | NOTUM (0.47) | AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | AMGEN INC. (US) | 2011-07-07 | — | — | US | disclosed |
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | PTGS2 2363/4885PTGS1 1721/4885CXCR1 4713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.