Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 15/20 | 0.42 |
| ▸ | USP2 | O75604 | 14/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21821240 | 0.95 | CYP3A4 (0.41) | CYP3A4USP2ALDH1A1HIF1ASMN1; SMN2 | |
| SCHEMBL29547862 | 0.87 | CYP11B2 (0.45) | CYP3A4USP2ALDH1A1HIF1ASMN1; SMN2 | |
| SCHEMBL19642261 | 0.87 | CYP11B2 (0.45) | CYP3A4USP2ALDH1A1HIF1ASMN1; SMN2 | |
| SCHEMBL29547484 | 0.84 | USP2 (0.38) | CYP3A4USP2ALDH1A1HIF1ASMN1; SMN2 | |
| SCHEMBL19642638 | 0.84 | USP2 (0.38) | CYP3A4USP2ALDH1A1HIF1ASMN1; SMN2 | |
| SCHEMBL29548330 | 0.84 | PARP1 (0.43) | CYP3A4USP2ALDH1A1HIF1ASMN1; SMN2 | |
| SCHEMBL19642409 | 0.84 | PARP1 (0.43) | CYP3A4USP2ALDH1A1HIF1ASMN1; SMN2 | |
| SCHEMBL19642370 | 0.82 | KHK (0.43) | CYP3A4USP2ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL29547976 | 0.82 | KHK (0.43) | CYP3A4USP2ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL19642402 | 0.81 | TTR (0.39) | CYP3A4ALDH1A1SMN1; SMN2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10611748-B2 | Xanthone derivatives for the treatment of hepatitis B virus disease | HOFFMANN-LA ROCHE INC. (US) | 2020-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10611748-B2 | Xanthone derivatives for the treatment of hepatitis B virus disease | XDH, XPOT, HAVCR2 | CYP3A4 205/4885USP2 3834/4885ALDH1A1 1704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.