Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2182202 | 1.00 | HIF1A (0.46) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL9467594 | 0.96 | HIF1A (0.43) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL2446001 | 0.96 | HIF1A (0.46) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL2445999 | 0.96 | HIF1A (0.46) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Iodide SCHEMBL8162433 | 0.96 | HIF1A (0.46) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Iodide SCHEMBL8162430 | 0.96 | HIF1A (0.46) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9180246 | 0.90 | HIF1A (0.41) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9180252 | 0.90 | HIF1A (0.41) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL8925807 | 0.86 | HIF1A (0.55) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL14839973 | 0.81 | HIF1A (0.55) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166080-A1 | DEUTERATED CYCLOSPORINE ANALOGS AND METHODS OF MAKING THE SAME | ISOTECHNIKA, INC. (CA) | 2011-07-07 | — | — | US | disclosed |
| US-7538084-B2 | Cyclosporins | AMR TECHNOLOGY, INC. (US) | 2009-05-26 | — | — | US | disclosed |
| EP-0991660-B8 | DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS | ISOTECHNIKA INC (CA) | 2006-04-05 | — | — | EP | disclosed |
| EP-1603512-A2 | NOVEL CYCLOSPORINS | Albany Molecular Research, Inc. (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20040235716-A1 | Novel cyclosporins | CURIA GLOBAL, INC. | 2004-11-25 | — | — | US | disclosed |
| WO-2004082629-A2 | NOVEL CYCLOSPORINS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2004-09-30 | — | — | WO | disclosed |
| EP-0991660-A1 | DEUTERATED CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS | Isotechnika, Inc. (CA) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999018120-A1 | DEUTERATED CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS | ISOTECHNIKA INC. (CA) | 1999-04-15 | — | — | WO | disclosed |
| US-5166208-A | Antitumor agents; antibiotics | BOSTON COLLEGE (US) | 1992-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166080-A1 | DEUTERATED CYCLOSPORINE ANALOGS AND METHODS OF MAKING THE SAME | CHP1, CYCS, CYC1 | ACHE 4742/4885HIF1A 873/4885TSHR 3365/4885 |
| US-20040235716-A1 | Novel cyclosporins | CHP1, IL2, CCR1 | ACHE 4885/4885HIF1A 3012/4885TSHR 4779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.