Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14839973 | 0.95 | HIF1A (0.55) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL2447465 | 0.95 | HIF1A (0.55) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL11584557 | 0.89 | HIF1A (0.44) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL16004643 | 0.89 | HIF1A (0.44) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL2182202 | 0.86 | HIF1A (0.46) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL16198009 | 0.86 | HIF1A (0.46) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL2182198 | 0.86 | HIF1A (0.46) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL9594079 | 0.85 | HIF1A (0.46) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL9594082 | 0.85 | HIF1A (0.46) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL3408959 | 0.85 | HIF1A (0.41) | HIF1AALDH1A1CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5623062-A | ELECTROPHOTOGRAPHIC PHOTOCONDUCTORS | RICOH COMPANY, LTD. (JP) | 1997-04-22 | — | — | US | disclosed |
| US-5344735-A | Organic photoconductors, laser printers | RICOH COMPANY, LTD. (JP) | 1994-09-06 | — | — | US | disclosed |