Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | CCR9 | P51686 | 7/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31689687 | 1.00 | NQO2 (0.37) | NQO2CCR2FDPSCCR9CTSS | |
| SCHEMBL31689662 | 0.91 | CTSS (0.42) | NQO2CCR2FDPSCCR9CTSS | |
| SCHEMBL21822737 | 0.91 | CTSS (0.42) | NQO2CCR2FDPSCCR9CTSS | |
| SCHEMBL21822553 | 0.83 | NQO2 (0.44) | NQO2CTSSCTSKF10 | |
| SCHEMBL25017640 | 0.81 | F10 (0.38) | F10 | |
| SCHEMBL31689683 | 0.81 | F10 (0.38) | F10 | |
| SCHEMBL28578446 | 0.81 | F10 (0.38) | F10 | |
| SCHEMBL21822320 | 0.81 | F10 (0.53) | CCR2FDPSF10GPR35 | |
| SCHEMBL31689695 | 0.81 | F10 (0.53) | CCR2FDPSF10GPR35 | |
| SCHEMBL21822377 | 0.80 | MCL1 (0.34) | CCR9MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860636-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | Disc Medicine, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-112996529-A | Matriptase 2 inhibitor and application thereof | 迪斯克医药公司 | 2021-06-18 | — | — | CN | disclosed |
| WO-2020072580-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. (US) | 2020-04-09 | — | — | WO | disclosed |