Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CCR9 | P51686 | 6/20 | 0.39 |
| ▸ | CCR2 | P41597 | 4/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31689662 | 1.00 | CTSS (0.42) | CTSSCTSKCCR9CCR2MCL1 | |
| SCHEMBL31689687 | 0.91 | NQO2 (0.37) | CTSSCTSKCCR9CCR2MCL1 | |
| SCHEMBL21822112 | 0.91 | NQO2 (0.37) | CTSSCTSKCCR9CCR2MCL1 | |
| SCHEMBL25016935 | 0.88 | F10 (0.43) | CCR2MCL1F10FDPSCMA1 | |
| SCHEMBL25015964 | 0.87 | CNR2 (0.39) | CTSSCTSKMCL1NQO2F10 | |
| SCHEMBL25016919 | 0.86 | CCR2 (0.39) | CCR9CCR2MCL1F10FDPS | |
| SCHEMBL25016775 | 0.86 | F10 (0.47) | F10 | |
| SCHEMBL25016107 | 0.85 | F10 (0.41) | NQO2F10 | |
| SCHEMBL25017943 | 0.85 | ACHE (0.43) | CTSSCTSKMCL1F10 | |
| SCHEMBL21822553 | 0.85 | NQO2 (0.44) | CTSSCTSKNQO2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860636-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | Disc Medicine, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-112996529-A | Matriptase 2 inhibitor and application thereof | 迪斯克医药公司 | 2021-06-18 | — | — | CN | disclosed |
| WO-2020072580-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. (US) | 2020-04-09 | — | — | WO | disclosed |