Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 7/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21822925 | 0.92 | CCR9 (0.49) | CCR9DRD4SLC6A5CCR2PRKAA2 | |
| SCHEMBL21822166 | 0.90 | CCR9 (0.48) | CCR9DRD4SLC6A5CCR2PRKAA2 | |
| SCHEMBL21822299 | 0.89 | DRD4 (0.50) | DRD4SLC6A5F10TEAD1SIGMAR1 | |
| SCHEMBL21822512 | 0.89 | DRD4 (0.50) | DRD4SLC6A5F10TEAD1SIGMAR1 | |
| SCHEMBL28915544 | 0.88 | CCR9 (0.47) | CCR9DRD4SLC6A5CCR2PRKAA2 | |
| SCHEMBL28588320 | 0.85 | SLC6A5 (0.48) | DRD4SLC6A5F10TEAD1DRD2 | |
| SCHEMBL28582742 | 0.83 | CCR9 (0.53) | CCR9DRD4CCR2PRKAA2F10 | |
| SCHEMBL28582741 | 0.83 | CCR9 (0.53) | CCR9DRD4CCR2PRKAA2F10 | |
| SCHEMBL21822127 | 0.82 | CCR9 (0.54) | CCR9DRD4CCR2PRKAA2F10 | |
| SCHEMBL21822290 | 0.81 | DRD4 (0.51) | DRD4SLC6A5F10TEAD1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860636-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | Disc Medicine, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-112996529-A | Matriptase 2 inhibitor and application thereof | 迪斯克医药公司 | 2021-06-18 | — | — | CN | disclosed |
| WO-2020072580-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. (US) | 2020-04-09 | — | — | WO | disclosed |