Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 18/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 8/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.39 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21822424 | 0.91 | F10 (0.44) | F10ITGB3ITGA2BF2 | |
| SCHEMBL25017861 | 0.89 | F10 (0.45) | F10ITGB3ITGA2BF2PRSS1 | |
| SCHEMBL25017373 | 0.89 | F10 (0.46) | F10ITGB3ITGA2BF2PRSS1 | |
| SCHEMBL21822135 | 0.86 | ITGB3 (0.40) | F10ITGB3ITGA2BF2PRSS1 | |
| SCHEMBL25016803 | 0.86 | F10 (0.47) | F10ITGB3ITGA2BF2PRSS1 | |
| SCHEMBL25017234 | 0.86 | F10 (0.49) | F10ITGB3ITGA2BF2PRSS1 | |
| SCHEMBL25016802 | 0.83 | ACKR3 (0.45) | F10ITGB3ITGA2BF2PRSS1 | |
| SCHEMBL21822498 | 0.83 | F10 (0.57) | F10F2 | |
| SCHEMBL28580200 | 0.80 | F10 (0.42) | F10F2PRSS1ST14 | |
| SCHEMBL25017867 | 0.78 | F2 (0.57) | F10ITGB3ITGA2BF2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860636-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | Disc Medicine, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| WO-2020072580-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. (US) | 2020-04-09 | — | — | WO | disclosed |