Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.44 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.44 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | GNRHR | P30968 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3449048 | 0.78 | CYP2C9 (0.53) | KDM4EPKMNAMPTCYP2C9BRD3 | |
| SCHEMBL3449051 | 0.78 | CYP2C9 (0.53) | KDM4EPKMNAMPTCYP2C9BRD3 | |
| SCHEMBL25016345 | 0.78 | RET (0.41) | RETKDR | |
| SCHEMBL22533699 | 0.77 | CYP2C9 (0.58) | KDM4EPKMNAMPTCYP2C9 | |
| SCHEMBL28573693 | 0.77 | KDM4E (0.51) | KDM4EPKMGNRHRRORC | |
| SCHEMBL21822456 | 0.76 | EIF4A3 (0.47) | KDM4EPLG | |
| SCHEMBL25015770 | 0.75 | KDM4E (0.49) | KDM4EPKMGNRHR | |
| SCHEMBL21822374 | 0.73 | ALOX15 (0.53) | KDM4EPLG | |
| SCHEMBL10144835 | 0.73 | KDM4E (0.76) | KDM4EPKMNAMPTGNRHR | |
| SCHEMBL3447178 | 0.73 | CYP2C9 (0.55) | KDM4EPKMNAMPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860636-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | Disc Medicine, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-112996529-A | Matriptase 2 inhibitor and application thereof | 迪斯克医药公司 | 2021-06-18 | — | — | CN | disclosed |
| WO-2020072580-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. (US) | 2020-04-09 | — | — | WO | disclosed |