Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.43 |
| ▸ | PLAU | P00749 | 3/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.43 |
| ▸ | ELANE | P08246 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21826680 | 1.00 | F2 (0.43) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL1856231 | 0.85 | F2 (0.40) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21826382 | 0.83 | F2 (0.48) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21826394 | 0.83 | F2 (0.48) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21826733 | 0.82 | F2 (0.44) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL21825683 | 0.82 | F2 (0.44) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL28618048 | 0.79 | F2 (0.43) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL1863155 | 0.77 | F2 (0.44) | F2PLAUKLKB1ELANEKMT2A | |
| SCHEMBL28994123 | 0.77 | ALDH1A1 (0.36) | ALDH1A1LMNACYP2C9MAPT | |
| SCHEMBL31105976 | 0.76 | PKM (0.52) | F2PLAUKLKB1ELANEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860976-A1 | INDOLINONE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | ICHNOS SCIENCES S.A. (CH) | 2021-08-11 | — | — | EP | disclosed |
| CN-113227049-A | Indolinone compounds as MAP4K1 inhibitors | 艾科诺斯科技股份有限公司 | 2021-08-06 | — | — | CN | disclosed |
| WO-2020070331-A1 | INDOLINONE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | ICHNOS SCIENCES S.A. (CH) | 2020-04-09 | — | — | WO | disclosed |