Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 3/20 | 0.61 |
| ▸ | ESR1 | P03372 | 3/20 | 0.61 |
| ▸ | CBS | P35520 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 6/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.41 |
| ▸ | RELA | Q04206 | 6/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179318 | 0.89 | ESR1 (0.61) | ESR2ESR1CYP19A1APP | |
| SCHEMBL2179159 | 0.88 | ESR1 (0.52) | ESR2ESR1NFKB1NFKB2RELA | |
| SCHEMBL2184401 | 0.83 | ESR1 (0.56) | ESR2ESR1CYP19A1APP | |
| SCHEMBL2181362 | 0.83 | ESR1 (0.53) | ESR2ESR1MEN1MAPTKMT2A | |
| SCHEMBL2184444 | 0.83 | ESR1 (0.55) | ESR2ESR1CYP19A1APP | |
| SCHEMBL9152189 | 0.79 | ESR1 (0.84) | ESR2ESR1 | |
| SCHEMBL2184277 | 0.78 | ESR1 (0.48) | ESR2ESR1APP | |
| SCHEMBL9153745 | 0.78 | ESR1 (0.98) | ESR2ESR1 | |
| SCHEMBL2182687 | 0.77 | ESR1 (0.50) | ESR2ESR1APP | |
| SCHEMBL7943653 | 0.77 | ESR1 (1.00) | ESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166142-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | NOVOGEN RESEARCH PTY LIMITED (AU) | 2011-07-07 | — | — | US | claimed |
| EP-2160385-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | Novogen Research Pty. Ltd. (AU) | 2010-03-10 | — | — | EP | claimed |
| WO-2009003229-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | NOVOGEN RESEARCH PTY LTD (AU) | 2009-01-08 | — | — | WO | claimed |
| US-20110166142-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | NOVOGEN RESEARCH PTY LIMITED (AU) | 2011-07-07 | — | — | US | disclosed |
| EP-2160385-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | Novogen Research Pty. Ltd. (AU) | 2010-03-10 | — | — | EP | disclosed |
| WO-2009003229-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | NOVOGEN RESEARCH PTY LTD (AU) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166142-A1 | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES | NFE2L2, PTGS2, PTGES2 | ESR2 8/4885ESR1 90/4885CBS 2014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.