Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120997 | 0.84 | APP (0.39) | APPHTR2CHTR6IDO1SCN2A | |
| SCHEMBL8765682 | 0.82 | APP (0.38) | APPHTR2CHTR6IDO1SCN2A | |
| SCHEMBL1049522 | 0.81 | ALDH1A1 (0.36) | CYP1A2CYP2D6CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL15750399 | 0.78 | ALDH1A1 (0.44) | APPHTR2CHTR6IDO1SCN2A | |
| SCHEMBL31354848 | 0.78 | ALDH1A1 (0.44) | APPHTR2CHTR6IDO1SCN2A | |
| SCHEMBL30253469 | 0.75 | APP (0.55) | APPHTR2CHTR6SCN2ARAB9A | |
| SCHEMBL1651699 | 0.75 | APP (0.55) | APPHTR2CHTR6SCN2ARAB9A | |
| SCHEMBL4936274 | 0.75 | ALDH1A1 (0.59) | APPHTR2CHTR6CYP1A2CYP2C19 | |
| SCHEMBL31037874 | 0.75 | ALDH1A1 (0.59) | APPHTR2CHTR6CYP1A2CYP2C19 | |
| SCHEMBL31037873 | 0.75 | ALDH1A1 (0.59) | APPHTR2CHTR6CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020063860-A1 | NAPHTHYRIDINONE AND PYRIDOPYRIMIDINONE COMPOUNDS USEFUL AS KINASES INHIBITORS | FOCHON PHARMACEUTICALS, LTD. (CN) | 2020-04-02 | — | — | WO | disclosed |
| CN-103974954-B | Kinase modulating compounds, compositions containing them and uses thereof | 北京赛林泰医药技术有限公司 | 2016-08-24 | — | — | CN | disclosed |