Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 4/20 | 0.58 |
| ▸ | EGFR | P00533 | 5/20 | 0.55 |
| ▸ | ITK | Q08881 | 2/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.54 |
| ▸ | BTK | Q06187 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | F13A1 | P00488 | 1/20 | 0.47 |
| ▸ | TGM1 | P22735 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043916 | 0.86 | TGM2 (0.63) | TGM2EGFRITKRAB9AMEN1 | |
| SCHEMBL9864914 | 0.83 | TGM2 (0.59) | TGM2EGFRITKGRM4BRD4 | |
| SCHEMBL1381244 | 0.83 | TGM2 (0.59) | TGM2EGFRITKF13A1TGM1 | |
| SCHEMBL194721 | 0.82 | KMT2A (0.56) | GRM4RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL194720 | 0.82 | KMT2A (0.56) | GRM4RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL23830553 | 0.82 | GRM4 (0.52) | GRM4RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL29700064 | 0.82 | KMT2A (0.56) | GRM4RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL30368161 | 0.81 | GRM4 (0.59) | GRM4RAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL7621031 | 0.80 | TGM2 (0.65) | TGM2EGFRITKBTKRAB9A | |
| SCHEMBL16523986 | 0.80 | TGM2 (0.59) | TGM2EGFRITKBTKF13A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112384508-B | Tricyclic ASK1 inhibitor and application thereof | 山东轩竹医药科技有限公司 | 2022-08-02 | — | — | CN | disclosed |
| EP-3883925-A1 | CYCLIC UREAS | Sironax Ltd (KY) | 2021-09-29 | — | — | EP | disclosed |
| CN-112384508-A | Tricyclic ASK1 inhibitor and application thereof | 山东轩竹医药科技有限公司 | 2021-02-19 | — | — | CN | disclosed |
| WO-2020063727-A1 | TRICYCLIC RING ASK1 INHIBITORS AND USE THEREOF | 山东轩竹医药科技有限公司 | 2020-04-02 | — | — | WO | disclosed |