Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | ITK | Q08881 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.55 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1381244 | 0.87 | TGM2 (0.59) | TGM2EGFRITKTRPV1 | |
| SCHEMBL9864914 | 0.87 | TGM2 (0.59) | TGM2EGFRITKSMN1; SMN2TP53 | |
| SCHEMBL28450293 | 0.86 | EGFR (0.58) | TGM2EGFRITK | |
| SCHEMBL14260335 | 0.86 | MAPT (0.59) | TGM2EGFRITKMAPTMEN1 | |
| SCHEMBL28455574 | 0.86 | EGFR (0.58) | TGM2EGFRITKSMN1; SMN2MAPT | |
| SCHEMBL12179325 | 0.86 | TGM2 (0.58) | TGM2EGFRITKSMN1; SMN2TP53 | |
| SCHEMBL9865437 | 0.86 | TGM2 (0.58) | TGM2EGFRITKSMN1; SMN2TP53 | |
| SCHEMBL21834411 | 0.86 | TGM2 (0.58) | TGM2EGFRITKALDH1A1RAB9A | |
| SCHEMBL30475564 | 0.86 | SMN1; SMN2 (0.72) | TGM2SMN1; SMN2TP53MAPTNPC1 | |
| SCHEMBL30230722 | 0.82 | TGM2 (0.54) | TGM2CYP1A2CYP2C19CYP2C9EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103435750-B | Hydrophobic associated polymer containing capsaicine activity monomer and preparation method thereof | OCEAN UNIVERSITY OF CHINA (CN) | 2015-10-21 | — | — | CN | claimed |
| CN-102580587-B | Capsaicin functional-group containing hydrophilic anti-biological-contamination ultrafiltration membrane and preparation method thereof | OCEAN UNIV CHINA | 2014-03-12 | — | — | CN | claimed |
| EP-0538262-A1 | N-DIMETHOXY PHENYL ALKYL-N'-IMIDAZOLYL PHENYL AMIDINE DERIVATIVES AND PROCESS THEREOF | IL YANG PHARM. CO., LTD. (KR) | 1993-04-28 | — | — | EP | claimed |
| WO-1992000966-A1 | N-DIMETHOXY PHENYL ALKYL-N'-IMIDAZOLYL PHENYL AMIDINE DERIVATIVES AND PROCESS THEREOF | IL YANG PHARM. CO., LTD. (KR) | 1992-01-23 | — | — | WO | claimed |
| CN-109369594-B | Myricetin derivative containing ferulic acid amide, and preparation method and application thereof | 贵州大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-103435750-B | Hydrophobic associated polymer containing capsaicine activity monomer and preparation method thereof | OCEAN UNIVERSITY OF CHINA (CN) | 2015-10-21 | — | — | CN | disclosed |
| CN-102580587-B | Capsaicin functional-group containing hydrophilic anti-biological-contamination ultrafiltration membrane and preparation method thereof | OCEAN UNIV CHINA | 2014-03-12 | — | — | CN | disclosed |
| CN-100497355-C | Hypophosphorous acid derivatives as beta-secretase inhibitors for the treatment of Alzheimer's disease | HOFFMANN LA ROCHE (CH) | 2009-06-10 | — | — | CN | disclosed |
| US-7345082-B2 | Phosphinic acids | HOFFMANN-LA ROCHE INC. (US) | 2008-03-18 | — | — | US | disclosed |
| EP-1685142-B1 | PHOSPHINIC ACID DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | disclosed |
| CN-1878781-A | Hypophosphorous acid derivatives as beta-secretase inhibitors for the treatment of Alzheimer's disease | HOFFMANN LA ROCHE (CH) | 2006-12-13 | — | — | CN | disclosed |
| EP-1685142-A1 | PHOSPHINIC ACID DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005044830-A1 | PHOSPHINIC ACIDS DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-19 | — | — | WO | disclosed |
| US-20050107341-A1 | Phosphinic acids | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-19 | — | — | US | disclosed |
| EP-0538262-A1 | N-DIMETHOXY PHENYL ALKYL-N'-IMIDAZOLYL PHENYL AMIDINE DERIVATIVES AND PROCESS THEREOF | IL YANG PHARM. CO., LTD. (KR) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000966-A1 | N-DIMETHOXY PHENYL ALKYL-N'-IMIDAZOLYL PHENYL AMIDINE DERIVATIVES AND PROCESS THEREOF | IL YANG PHARM. CO., LTD. (KR) | 1992-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107341-A1 | Phosphinic acids | BACE1, PSEN1, PSEN2 | TGM2 1013/4885CYP1A2 2690/4885CYP2C19 2204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.