Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21818930 | 1.00 | ATM (0.42) | ATMALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL19078479 | 0.91 | ATM (0.41) | ATMALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL25765744 | 0.83 | ATM (0.38) | ATMALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL6536207 | 0.82 | ALDH1A1 (0.40) | ATMALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL25230409 | 0.80 | ALDH1A1 (0.42) | ATMALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL973127 | 0.80 | KLK7 (0.49) | PARP1UCHL1 | |
| SCHEMBL3805159 | 0.80 | HSD17B10 (0.42) | ATMALDH1A1HSD17B10NPC1UCHL1 | |
| SCHEMBL4766170 | 0.80 | HSD17B10 (0.42) | ATMALDH1A1HSD17B10NPC1UCHL1 | |
| Acetic Acid SCHEMBL11305411 | 0.79 | CYP2D6 (0.38) | ATMALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL31603663 | 0.78 | MEN1 (0.42) | ATMALDH1A1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856178-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | Janssen Pharmaceutica NV (BE) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020065613-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-02 | — | — | WO | disclosed |