Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18410805 | 0.90 | ALDH1A1 (0.57) | ALDH1A1KMT2ALMNAPOLBMAPT | |
| SCHEMBL10036389 | 0.84 | ALDH1A1 (0.54) | ALDH1A1KMT2ALMNAPOLBMAPT | |
| SCHEMBL7818416 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KMT2ALMNAPOLBMAPT | |
| SCHEMBL4291603 | 0.80 | ALDH1A1 (0.55) | ALDH1A1KMT2ALMNAPOLBMAPT | |
| SCHEMBL3026496 | 0.79 | ALDH1A1 (0.68) | ALDH1A1KMT2ALMNAPOLBMAPT | |
| SCHEMBL25797079 | 0.79 | CRBN (0.52) | ALDH1A1KMT2ALMNAPOLBMAPT | |
| SCHEMBL27178792 | 0.79 | ALDH1A1 (0.60) | ALDH1A1KMT2ALMNAPOLBMAPT | |
| SCHEMBL14464189 | 0.78 | ALDH1A1 (0.79) | ALDH1A1KMT2ALMNAPOLBMAPT | |
| SCHEMBL21672036 | 0.78 | MAPT (0.48) | ALDH1A1KMT2ALMNAPOLBMAPT | |
| SCHEMBL21634817 | 0.78 | ALDH1A1 (0.39) | ALDH1A1KMT2ALMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528810-B2 | Small molecule inhibitors of DYRK/CLK and uses thereof | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2026-01-20 | — | — | US | disclosed |
| US-20250051325-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2025-02-13 | — | — | US | disclosed |
| US-12054483-B2 | Small molecule inhibitors of DYRK/CLK and uses thereof | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2024-08-06 | — | — | US | disclosed |
| US-20220041590-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2022-02-10 | — | — | US | disclosed |
| EP-3856186-A1 | SMALL MOLECULE INHIBITORS OF DYRK1/CLK AND USES THEREOF | Arizona Board of Regents on behalf of the University of Arizona (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020069418-A1 | SMALL MOLECULE INHIBITORS OF DYRK1/CLK AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2020-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12528810-B2 | Small molecule inhibitors of DYRK/CLK and uses thereof | CLK3, CLK2, CLK1 | ALDH1A1 3885/4885KMT2A 1120/4885LMNA 3740/4885 |
| US-20220041590-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | CLK2, CLK1, CLK3 | ALDH1A1 2781/4885KMT2A 1688/4885LMNA 3111/4885 |
| US-12054483-B2 | Small molecule inhibitors of DYRK/CLK and uses thereof | CLK2, CLK1, CLK3 | ALDH1A1 2781/4885KMT2A 1688/4885LMNA 3111/4885 |
| US-20250051325-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | CLK2, CLK1, CLK3 | ALDH1A1 2781/4885KMT2A 1688/4885LMNA 3111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.