Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970751 | 0.86 | KDM4E (0.43) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL24375889 | 0.81 | F2 (0.41) | ALDH1A1HPGDKDM4ECYP1A2KMT2A | |
| SCHEMBL2423817 | 0.80 | KDM4E (0.47) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL3809367 | 0.78 | CYP1A2 (0.53) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL162807 | 0.78 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL8647610 | 0.77 | CYP1A2 (0.41) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL20595215 | 0.77 | KDM4E (0.45) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL8552985 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL19358702 | 0.77 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL38659549 | 0.77 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EHTTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025026903-A1 | IMIDAZO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | BAYER AKTIENGESELLSCHAFT (DE) | 2025-02-06 | — | — | WO | disclosed |
| EP-3642199-B1 | BENZOFURANS AS IRAK4 MODULATORS | HOFFMANN LA ROCHE (CH) | 2022-04-27 | — | — | EP | disclosed |
| EP-3642199-B1 | BENZOFURANS AS IRAK4 MODULATORS | HOFFMANN LA ROCHE (CH) | 2022-04-27 | — | — | EP | disclosed |
| US-10899774-B2 | IRAK4 modulators | GENENTECH, INC. (US) | 2021-01-26 | — | — | US | disclosed |
| US-20200115388-A1 | IRAK4 MODULATORS | GENENTECH, INC. (US) | 2020-04-16 | — | — | US | disclosed |
| US-20200115388-A1 | IRAK4 MODULATORS | GENENTECH, INC. (US) | 2020-04-16 | — | — | US | disclosed |
| CN-110770229-A | Benzofuran compounds as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2020-02-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10899774-B2 | IRAK4 modulators | IRAK4, IRAK1, IRAK2 | ALDH1A1 1862/4885HPGD 4718/4885KDM4E 761/4885 |
| US-20200115388-A1 | IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | ALDH1A1 1862/4885HPGD 4718/4885KDM4E 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.