Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22132035 | 0.88 | EPHX1 (0.44) | MEN1KMT2AACACBACACAEPHX1 | |
| SCHEMBL22131907 | 0.86 | MAPK1 (0.40) | ACACBACACAEPHX1MTNR1AMTNR1B | |
| SCHEMBL27369636 | 0.84 | MEN1 (0.36) | MEN1KMT2AEPHX2MTNR1AMTNR1B | |
| SCHEMBL13455632 | 0.82 | EPHX2 (0.33) | MEN1KMT2AACACBACACAEPHX2 | |
| SCHEMBL19309079 | 0.80 | MEN1 (0.56) | MEN1KMT2AMTNR1AMTNR1BMAPK1 | |
| SCHEMBL5155263 | 0.80 | MEN1 (0.56) | MEN1KMT2AMTNR1AMTNR1BMAPK1 | |
| SCHEMBL21842362 | 0.79 | KDM4E (0.52) | ACACBACACAEPHX1EPHX2MAPK1 | |
| SCHEMBL5157716 | 0.78 | MAPK1 (0.55) | MEN1KMT2AMTNR1AMTNR1BMAPK1 | |
| SCHEMBL21842363 | 0.77 | MEN1 (0.42) | MEN1KMT2AEPHX1EPHX2KDM4E | |
| SCHEMBL14407371 | 0.75 | EPHX1 (0.40) | MEN1KMT2AEPHX1EPHX2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020069125-A1 | DEGRADERS OF HEPATITIS C VIRUS NS3/4A PROTEIN | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-02 | — | — | WO | disclosed |