Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 11/20 | 0.77 |
| ▸ | RAF1 | P04049 | 2/20 | 0.73 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | THRB | P10828 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.73 |
| ▸ | RECQL | P46063 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | GALK1 | P51570 | 2/20 | 0.73 |
| ▸ | BLM | P54132 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.73 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2180580 | 0.84 | TDP2 (1.00) | TDP2RAF1MAP2K1KDM4ENPC1 | |
| SCHEMBL2183740 | 0.84 | TDP2 (1.00) | TDP2RAF1MAP2K1KDM4ENPC1 | |
| SCHEMBL2183068 | 0.84 | TDP2 (0.74) | TDP2RAF1MAP2K1KDM4ENPC1 | |
| SCHEMBL15032639 | 0.82 | TDP2 (0.73) | TDP2RAF1MAP2K1KDM4ENPC1 | |
| SCHEMBL14020030 | 0.81 | TDP2 (0.73) | TDP2RAF1MAP2K1KDM4ENPC1 | |
| SCHEMBL2182141 | 0.81 | TDP2 (0.71) | TDP2RAF1MAP2K1KDM4ENPC1 | |
| SCHEMBL2181779 | 0.79 | TDP2 (1.00) | TDP2RAF1MAP2K1KDM4ENPC1 | |
| SCHEMBL13272626 | 0.79 | TDP2 (0.74) | TDP2RAF1MAP2K1KDM4ENPC1 | |
| SCHEMBL15032575 | 0.79 | TDP2 (1.00) | TDP2RAF1MAP2K1KDM4ENPC1 | |
| SCHEMBL3472993 | 0.78 | KDM4C (1.00) | TDP2RAF1MAP2K1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | DPYD, TYMP, DHFR | TDP2 685/4885RAF1 2577/4885MAP2K1 2120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.