Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15812284 | 0.82 | MET (0.44) | METMAPT | |
| SCHEMBL487861 | 0.81 | MET (0.57) | METJAK2MAP4K3 | |
| SCHEMBL30453222 | 0.81 | MET (0.57) | METJAK2MAP4K3 | |
| SCHEMBL10215095 | 0.80 | MET (0.64) | METNPC1MAPTRAB9A | |
| SCHEMBL10215090 | 0.75 | JAK2 (0.58) | METJAK2MAP4K3 | |
| SCHEMBL15338633 | 0.75 | IDO1 (0.47) | METMAPT | |
| SCHEMBL15663813 | 0.74 | MET (0.50) | METJAK2MAP4K3NPC1MAPT | |
| SCHEMBL9124987 | 0.74 | MET (0.56) | METJAK2MAP4K3NPC1MAPT | |
| SCHEMBL7502815 | 0.74 | MET (0.46) | METMAPT | |
| SCHEMBL17224826 | 0.73 | MET (0.45) | METJAK2MAP4K3NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020069106-A1 | DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-02 | — | — | WO | disclosed |