Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 18/20 | 0.45 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21895629 | 0.79 | KRAS (0.38) | KRASTEAD3 | |
| SCHEMBL19637273 | 0.78 | KRAS (0.73) | KRAS | |
| SCHEMBL30188853 | 0.78 | KRAS (0.73) | KRAS | |
| SCHEMBL19636782 | 0.75 | KRAS (0.73) | KRAS | |
| SCHEMBL21895574 | 0.75 | KRAS (0.39) | KRAS | |
| SCHEMBL19617378 | 0.72 | KRAS (0.72) | KRAS | |
| SCHEMBL19637068 | 0.72 | KRAS (0.72) | KRAS | |
| SCHEMBL19637211 | 0.72 | KRAS (0.72) | KRAS | |
| SCHEMBL30189133 | 0.72 | KRAS (0.72) | KRAS | |
| SCHEMBL22087281 | 0.72 | KRAS (0.40) | KRASTEAD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055756-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |
| WO-2020055760-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |