Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 18/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21895629 | 0.95 | KRAS (0.38) | KRASJAK3BTK | |
| SCHEMBL22994733 | 0.84 | JAK3 (0.40) | KRASJAK3BTK | |
| SCHEMBL22994767 | 0.80 | BTK (0.44) | KRASJAK3BTK | |
| SCHEMBL21896284 | 0.80 | KRAS (0.40) | KRASJAK3BTK | |
| SCHEMBL21895605 | 0.80 | KRAS (0.43) | KRASJAK3BTK | |
| SCHEMBL19637080 | 0.80 | KRAS (0.31) | KRAS | |
| SCHEMBL22994789 | 0.78 | KRAS (0.44) | KRASJAK3 | |
| SCHEMBL21846333 | 0.75 | KRAS (0.45) | KRAS | |
| SCHEMBL22994731 | 0.74 | NUDT1 (0.38) | KRASJAK3BTK | |
| SCHEMBL19637398 | 0.74 | CSF1R (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055756-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |