Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4802257 | 0.75 | CYP19A1 (0.52) | GRM5PDE4BELANECDC7CDK2 | |
| SCHEMBL5216403 | 0.73 | GRM5 (0.74) | GRM5NOTUMKDM4EALDH1A1MAPT | |
| SCHEMBL2294384 | 0.72 | CDC7 (0.53) | KDM4EMAPTCDC7CDK2 | |
| SCHEMBL3922456 | 0.70 | GRM5 (1.00) | GRM5KDM4EALDH1A1MAPTTSHR | |
| SCHEMBL30795243 | 0.70 | GRM5 (1.00) | GRM5KDM4EALDH1A1MAPTTSHR | |
| SCHEMBL2295440 | 0.69 | CDC7 (0.56) | KDM4ECDC7CDK2 | |
| SCHEMBL3921645 | 0.69 | GRM5 (0.58) | GRM5NOTUM | |
| SCHEMBL4801964 | 0.69 | CDC7 (0.41) | CDC7CDK2 | |
| SCHEMBL30405693 | 0.68 | CDC7 (0.51) | PTK2KDM4EMAPTHTTCDC7 | |
| SCHEMBL415753 | 0.68 | CDC7 (0.51) | PTK2KDM4EMAPTHTTCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343299-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2011-07-13 | — | — | EP | disclosed |