Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 17/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 17/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 12/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4900829 | 0.82 | MAPT (0.47) | KCNJ6KCNJ3KCNJ5KDM4EALDH1A1 | |
| SCHEMBL1695151 | 0.79 | KDM4E (0.47) | KCNJ6KCNJ3KCNJ5POLBKDM4E | |
| SCHEMBL1695184 | 0.79 | ALDH1A1 (0.44) | KCNJ6KCNJ3KCNJ5POLBKDM4E | |
| SCHEMBL14785716 | 0.78 | POLB (0.41) | POLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1695102 | 0.77 | KDM4E (0.50) | KCNJ6KCNJ3KCNJ5POLBKDM4E | |
| SCHEMBL1695005 | 0.74 | GAA (0.54) | POLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL11688080 | 0.74 | MAPK1 (0.41) | POLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1694604 | 0.71 | KCNJ6 (0.39) | KCNJ6KCNJ3KCNJ5POLBKDM4E | |
| SCHEMBL28627037 | 0.70 | POLB (0.38) | POLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL21597663 | 0.69 | PIK3CA (0.41) | KCNJ6KCNJ3KCNJ5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |