Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KCNJ6 | P48051 | 9/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 9/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 8/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695151 | 0.98 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10HPGDKCNJ6 | |
| SCHEMBL1695184 | 0.94 | ALDH1A1 (0.44) | KDM4EALDH1A1HSD17B10HPGDKCNJ6 | |
| SCHEMBL14785716 | 0.90 | POLB (0.41) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL11688080 | 0.82 | MAPK1 (0.41) | KDM4EALDH1A1HSD17B10HPGDPDE7A | |
| SCHEMBL1695005 | 0.82 | GAA (0.54) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL1694604 | 0.82 | KCNJ6 (0.39) | KDM4EALDH1A1HSD17B10HPGDKCNJ6 | |
| SCHEMBL3364096 | 0.81 | ALDH1A1 (0.49) | KDM4EALDH1A1HSD17B10HPGDKCNJ6 | |
| SCHEMBL31462462 | 0.81 | ALDH1A1 (0.49) | KDM4EALDH1A1HSD17B10HPGDKCNJ6 | |
| SCHEMBL18692782 | 0.79 | HPGD (0.43) | KDM4EALDH1A1HSD17B10HPGDPDE7A | |
| SCHEMBL23748795 | 0.79 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10HPGDKCNJ6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848591-B | HDAC inhibitors and methods of making and using the same | 成都先导药物开发股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-111848591-A | HDAC inhibitors and methods of making and using the same | 成都先导药物开发股份有限公司 | 2020-10-30 | — | — | CN | disclosed |
| WO-2020216298-A1 | HDAC INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 成都先导药物开发股份有限公司 | 2020-10-29 | — | — | WO | disclosed |
| EP-3359541-B1 | N-SULFONYLATED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | ABBVIE OVERSEAS SARL (LU) | 2020-08-05 | — | — | EP | disclosed |
| US-10647717-B2 | N-sulfonylated-pyrazolo[3,4-b]pyridin-6-carboxamides and method of use | ABBVIE S.Á.R.L. (LU) | 2020-05-12 | — | — | US | disclosed |
| US-10647717-B2 | N-sulfonylated-pyrazolo[3,4-b]pyridin-6-carboxamides and method of use | ABBVIE S.Á.R.L. (LU) | 2020-05-12 | — | — | US | disclosed |
| US-20190330207-A1 | N-Sulfonylated-Pyrazolo[3,4-b]Pyridin-6-Carboxamides and Method of Use | ABBVIE SARL (LU) | 2019-10-31 | — | — | US | disclosed |
| US-20190330207-A1 | N-Sulfonylated-Pyrazolo[3,4-b]Pyridin-6-Carboxamides and Method of Use | ABBVIE SARL (LU) | 2019-10-31 | — | — | US | disclosed |
| US-20190202823-A1 | N-SULFONYLATED PYRAZOLO[3,4-b]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | ABBVIE SARL (LU) | 2019-07-04 | — | — | US | disclosed |
| US-10272074-B2 | Inhibitors of glucocorticoid receptor translocation | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-04-30 | — | — | US | disclosed |
| WO-2013039988-A1 | AZAINDAZOLES | GLAX0SMITHKLINE LLC (US) | 2013-03-21 | — | — | WO | disclosed |
| EP-2566479-A1 | AZAINDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| US-20130059849-A1 | AZAINDAZOLES | GLAXOSMITHKLINE LLC | 2013-03-07 | — | — | US | disclosed |
| WO-2012005805-A1 | AZAINDAZOLES | GLAXOSMITHKLINE LLC (US) | 2012-01-12 | — | — | WO | disclosed |
| US-4243584-A | Monoazo dyestuffs containing diazo component substituted by disulfimide and trifluoromethyl groups | BAYER AKTIENGESELLSCHAFT (DE) | 1981-01-06 | — | — | US | disclosed |
| US-4159265-A | Phenylazopyrazolo dyestuffs including disulfimide substituent | BAYER AKTIENGESELLSCHAFT (DE) | 1979-06-26 | — | — | US | disclosed |
| US-4113718-A | Basic azo dyes | CIBA-GEIGY CORPORATION (US) | 1978-09-12 | — | — | US | disclosed |
| US-4055557-A | MONOAZO DYES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-10-25 | — | — | US | disclosed |
| US-4026931-A | AZO DYES, FIBER-REACTIVE; INDOLE OR 5-AMINO-PYRAZOLE COUPLING COMPONENT | BAYER AKTIENGESELLSCHAFT (DT) | 1977-05-31 | — | — | US | disclosed |
| US-4006127-A | Cationic diazacyanine dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1977-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190330207-A1 | N-Sulfonylated-Pyrazolo[3,4-b]Pyridin-6-Carboxamides and Method of Use | CFTR, CHRM3, P2RY1 | KDM4E 4665/4885ALDH1A1 3177/4885HSD17B10 4796/4885 |
| US-20190202823-A1 | N-SULFONYLATED PYRAZOLO[3,4-b]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | CFTR, P2RY1, P2RX5 | KDM4E 4713/4885ALDH1A1 3001/4885HSD17B10 4680/4885 |
| US-10647717-B2 | N-sulfonylated-pyrazolo[3,4-b]pyridin-6-carboxamides and method of use | CFTR, CHRM3, P2RY1 | KDM4E 4665/4885ALDH1A1 3177/4885HSD17B10 4796/4885 |
| US-20130059849-A1 | AZAINDAZOLES | AZI2, MKI67, DNMT1 | KDM4E 682/4885ALDH1A1 114/4885HSD17B10 945/4885 |
| US-10272074-B2 | Inhibitors of glucocorticoid receptor translocation | NR3C1, NR3C2, GRK3 | KDM4E 3499/4885ALDH1A1 3958/4885HSD17B10 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.