Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 17/20 | 0.45 |
| ▸ | TAF1 | P21675 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23660707 | 0.87 | BRD4 (0.49) | BRD9BRD4 | |
| SCHEMBL21846905 | 0.78 | BRD4 (0.40) | CECR2BRD4 | |
| SCHEMBL20384475 | 0.72 | BRD4 (0.53) | CECR2BRD9BRD4TAF1 | |
| SCHEMBL17748893 | 0.69 | BRD9 (0.71) | CECR2BRD9BRD4TAF1 | |
| SCHEMBL21847808 | 0.67 | ALDH1A1 (0.42) | — | |
| SCHEMBL17492693 | 0.66 | BRD4 (0.66) | BRD9BRD4 | |
| SCHEMBL17492768 | 0.66 | BRD4 (0.68) | BRD4 | |
| SCHEMBL22600098 | 0.65 | BRD4 (0.58) | CECR2BRD9BRD4TAF1 | |
| SCHEMBL28573307 | 0.64 | BRD4 (0.58) | CECR2BRD9BRD4TAF1 | |
| SCHEMBL17748876 | 0.64 | BRD4 (0.74) | CECR2BRD9BRD4TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055976-A1 | TERT-BUTYL (S)-2-(4-(PHENYL)-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A] [1,4]DIAZEPIN-6-YL) ACETATE DERIVATIVES AND RELATED COMPOUNDS AS BROMODOMAIN BRD4 INHIBITORS FOR TREATING CANCER | GENENTECH, INC. (US) | 2020-03-19 | — | — | WO | disclosed |