SCHEMBL21848460

SCHEMBL21848460

Cc1cc([C@@H](N)Cc2ccc(I)cc2)nc2ccccc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.44
CYP1A2 P05177 3/20 0.43
KDM4E B2RXH2 4/20 0.41
ALDH1A1 P00352 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
HPGD P15428 1/20 0.41
NPFFR1 Q9GZQ6 1/20 0.39
NPFFR2 Q9Y5X5 1/20 0.39
L3MBTL1 Q9Y468 3/20 0.37
MAPT P10636 2/20 0.37
LMNA P02545 1/20 0.37
TP53 P04637 1/20 0.37
CYP1A1 P04798 2/20 0.37
CYP1B1 Q16678 2/20 0.37
RAB9A P51151 2/20 0.37
POLB P06746 1/20 0.37
GAA P10253 2/20 0.36
PRNP P04156 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
ACHE P22303 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21848466 0.90 BACE1 (0.50) BACE1CYP1A2KDM4EALDH1A1SMN1; SMN2
SCHEMBL28459551 0.80 GRM2 (0.39) BACE1CYP1A2KDM4EALDH1A1SMN1; SMN2
SCHEMBL21848459 0.74 BACE1 (0.47) BACE1CYP1A2KDM4EALDH1A1SMN1; SMN2
SCHEMBL21848468 0.74 BACE1 (0.58) BACE1CYP1A2KDM4EALDH1A1SMN1; SMN2
SCHEMBL21848470 0.73 BACE1 (0.46) BACE1CYP1A2KDM4EALDH1A1SMN1; SMN2
SCHEMBL21834813 0.73 PTPRB (0.46) ALDH1A1SMN1; SMN2HPGDMAPTLMNA
SCHEMBL21848545 0.72 ACACA (0.40) KDM4EMAPT
SCHEMBL21848469 0.71 BACE1 (0.54) BACE1CYP1A2KDM4EALDH1A1SMN1; SMN2
SCHEMBL2600753 0.70 CYP1A2 (0.60) BACE1CYP1A2KDM4EALDH1A1SMN1; SMN2
SCHEMBL8125169 0.70 CYP1A2 (0.51) BACE1CYP1A2KDM4EALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020063399-A1 METHOD FOR LIGHT-INDUCED DECARBOXYLATION COUPLING OF ACTIVE CARBOXYLIC ACID ESTER UNDER NON-METAL CATALYSIS 中国科学技术大学 2020-04-02 WO disclosed