Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2182894 | 1.00 | ACE (0.43) | ACEAKR1C3AKR1C1GABRR1PLG | |
| SCHEMBL4416794 | 1.00 | ACE (0.43) | ACEAKR1C3AKR1C1GABRR1PLG | |
| SCHEMBL30839239 | 1.00 | ACE (0.43) | ACEAKR1C3AKR1C1GABRR1PLG | |
| SCHEMBL3099849 | 1.00 | ACE (0.43) | ACEAKR1C3AKR1C1GABRR1PLG | |
| SCHEMBL1345147 | 1.00 | ACE (0.43) | ACEAKR1C3AKR1C1GABRR1PLG | |
| SCHEMBL16392460 | 1.00 | ACE (0.43) | ACEAKR1C3AKR1C1GABRR1PLG | |
| SCHEMBL2184629 | 1.00 | ACE (0.43) | ACEAKR1C3AKR1C1GABRR1PLG | |
| SCHEMBL1344569 | 1.00 | ACE (0.43) | ACEAKR1C3AKR1C1GABRR1PLG | |
| SCHEMBL2932019 | 1.00 | ACE (0.43) | ACEAKR1C3AKR1C1GABRR1PLG | |
| SCHEMBL11155834 | 0.84 | GABRR1 (0.48) | ACEAKR1C3AKR1C1GABRR1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040259-B2 | Production of polyketides and other natural products | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2015-05-26 | — | — | US | claimed |
| US-20110165633-A1 | Production of Polyketides and Other Natural Products | BUCK INSTITUTE FOR RESEARCH ON AGING | 2011-07-07 | — | — | US | claimed |
| US-20080287482-A1 | Production of Polyketides and Other Natural Products | GREGORY MATTHEW ALAN | 2008-11-20 | — | — | US | claimed |
| EP-1967520-A2 | Production of polyketides and other natural products | Biotica Technology Limited (GB) | 2008-09-10 | — | — | EP | claimed |
| EP-1589031-B1 | Production of polyketides and other natural products | BIOTICA TECH LTD (GB) | 2007-08-15 | — | — | EP | claimed |
| EP-1655372-A2 | Production of polyketides and other natural products | Biotica Technology Limited (GB) | 2006-05-10 | — | — | EP | claimed |
| US-20050272132-A1 | Production of polyketides and other natural products | BIOTICA TECHNOLOGY LIMITED (GB) | 2005-12-08 | — | — | US | claimed |
| EP-1589031-A2 | Production of polyketides and other natural products | Biotica Technology Limited (GB) | 2005-10-26 | — | — | EP | claimed |
| US-9605001-B2 | Production of polyketides and other natural products | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150266896-A1 | PRODUCTION OF POLYKETIDES AND OTHER NATURAL PRODUCTS | BIOTICA TECH LTD (GB) | 2015-09-24 | — | — | US | disclosed |
| EP-1521828-B1 | PRODUCTION OF POLYKETIDES | BUCK INST FOR RES ON AGING (US) | 2015-07-01 | — | — | EP | disclosed |
| US-9040259-B2 | Production of polyketides and other natural products | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2015-05-26 | — | — | US | disclosed |
| US-20110165633-A1 | Production of Polyketides and Other Natural Products | BUCK INSTITUTE FOR RESEARCH ON AGING | 2011-07-07 | — | — | US | disclosed |
| US-7645768-B2 | Production of polyketides and other natural products | WYETH (US) | 2010-01-12 | — | — | US | disclosed |
| EP-1655372-A2 | Production of polyketides and other natural products | Biotica Technology Limited (GB) | 2006-05-10 | — | — | EP | disclosed |
| US-20060078980-A1 | Production of polyketides and other natural products | GREGORY MATTHEW A | 2006-04-13 | — | — | US | disclosed |
| US-20050272132-A1 | Production of polyketides and other natural products | BIOTICA TECHNOLOGY LIMITED (GB) | 2005-12-08 | — | — | US | disclosed |
| EP-1589031-A2 | Production of polyketides and other natural products | Biotica Technology Limited (GB) | 2005-10-26 | — | — | EP | disclosed |
| EP-1521828-A2 | PRODUCTION OF POLYKETIDES | Biotica Technology Limited (GB) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004007709-A2 | PRODUCTION OF POLYKETIDES | BIOTICA TECHNOLOGY LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266896-A1 | PRODUCTION OF POLYKETIDES AND OTHER NATURAL PRODUCTS | FKBP14, FKBP4, FKBP2 | ACE 3791/4885AKR1C3 492/4885AKR1C1 664/4885 |
| US-20080287482-A1 | Production of Polyketides and Other Natural Products | FKBP14, FKBP4, FKBP2 | ACE 3791/4885AKR1C3 492/4885AKR1C1 664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.