Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 5/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.38 |
| ▸ | HTR3B | O95264 | 4/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | USP14 | P54578 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2182669 | 0.90 | CHEK1 (0.43) | CHEK1CHEK2HTR3AHTR3EHTR3B | |
| SCHEMBL2183601 | 0.90 | HSP90AA1 (0.45) | HSP90AA1USP14 | |
| SCHEMBL2183606 | 0.90 | HSP90AA1 (0.45) | HSP90AA1USP14 | |
| SCHEMBL2182947 | 0.90 | HSP90AA1 (0.45) | CHEK1CHEK2HSP90AA1 | |
| Hydrochloric Acid SCHEMBL2184372 | 0.90 | CHEK1 (0.43) | CHEK1CHEK2HTR3AHTR3EHTR3B | |
| SCHEMBL2183173 | 0.89 | HSP90AA1 (0.40) | CHEK1CHEK2HSP90AA1GPR119USP14 | |
| SCHEMBL2183571 | 0.88 | HSP90AA1 (0.34) | CHEK1CHEK2HSP90AA1GPR119USP14 | |
| SCHEMBL2181941 | 0.82 | GPR119 (0.36) | GPR119USP14PDE10A | |
| SCHEMBL2183331 | 0.82 | USP14 (0.34) | HSP90AA1GPR119USP14 | |
| SCHEMBL2182539 | 0.81 | USP14 (0.33) | CHEK1CHEK2HSP90AA1GPR119USP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309721-B2 | HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof | SANOFI (FR) | 2012-11-13 | — | — | US | disclosed |
| US-20110166169-A1 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | SANOFI-AVENTIS (FR) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166169-A1 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | HSP90AB2P, HSP90AB1, HSP90AA1 | CHEK1 2282/4885CHEK2 2483/4885HTR3A 790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.