Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 4/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21850860 | 0.78 | SCD (0.40) | LMNAKCNJ1CYP1A2SCDSIGMAR1 | |
| SCHEMBL21850829 | 0.77 | LMNA (0.43) | LMNAKCNJ1CYP1A2CHRM2SLC6A4 | |
| SCHEMBL28838407 | 0.74 | LMNA (0.50) | LMNACYP1A2CHRM2SLC6A4OPRD1 | |
| SCHEMBL21850857 | 0.73 | CYP1A2 (0.44) | LMNAKCNJ1CYP1A2CHRM2SLC6A4 | |
| SCHEMBL21851152 | 0.72 | DDR1 (0.40) | LMNAMELK | |
| SCHEMBL30478293 | 0.70 | LMNA (0.47) | LMNACYP1A2CHRM2SLC6A4OPRD1 | |
| SCHEMBL21850871 | 0.70 | KCNJ1 (0.49) | LMNAKCNJ1CHRM2SIGMAR1CXCR4 | |
| SCHEMBL20744521 | 0.68 | LMNA (0.48) | LMNACYP1A2CHRM2SLC6A4OPRD1 | |
| SCHEMBL15093925 | 0.68 | LMNA (0.57) | LMNACYP1A2CHRM2SLC6A4OPRD1 | |
| SCHEMBL24135549 | 0.67 | CYP2E1 (0.40) | LMNACYP1A2SIGMAR1CXCR4HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200109135-A1 | SUBSTITUTED NITROGEN CONTAINING COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200109135-A1 | SUBSTITUTED NITROGEN CONTAINING COMPOUNDS | NR0B1, GRK1, GRIN1 | LMNA 610/4885KCNJ1 562/4885CYP1A2 1414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.