Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2185192 | 0.98 | CA1 (0.39) | CA1CA2POLBTSHRHPGD | |
| SCHEMBL5257406 | 0.93 | KMT2A (0.37) | CA1CA2POLBTSHRHPGD | |
| 1,2-Dichlorobenzene SCHEMBL27756619 | 0.83 | ALDH1A1 (0.59) | POLBTSHRHPGDKMT2AALDH1A1 | |
| Cyclopropane SCHEMBL27924381 | 0.82 | KDM4E (0.47) | CA2KMT2AALDH1A1KDM4EMAPT | |
| Fluorobenzene SCHEMBL27883519 | 0.82 | TSHR (0.51) | TSHRHPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL83829 | 0.78 | MEN1 (0.32) | KMT2AMEN1 | |
| SCHEMBL12821513 | 0.78 | KDM4E (0.42) | KMT2AALDH1A1KDM4EMAPTUSP2 | |
| SCHEMBL2186346 | 0.78 | CA12 (0.48) | POLBTSHRALDH1A1KDM4EMAPT | |
| SCHEMBL2187580 | 0.78 | KDM4E (0.42) | KMT2AALDH1A1KDM4EMAPTUSP2 | |
| SCHEMBL2186390 | 0.77 | ALDH1A1 (0.36) | KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346507-A1 | USE OF QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | Boehringer Ingelheim International GmbH (DE) | 2011-07-27 | — | — | EP | claimed |
| WO-2010026029-A1 | USE OF QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | claimed |
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | disclosed |