Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.52 |
| ▸ | KLK7 | P49862 | 3/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1371898 | 0.81 | S1PR1 (0.69) | S1PR1FNTAFNTBSCN9A | |
| SCHEMBL1371900 | 0.81 | S1PR1 (0.69) | S1PR1FNTAFNTBSCN9A | |
| SCHEMBL2357200 | 0.79 | S1PR1 (0.48) | S1PR1FNTAFNTBMAPTSMN1; SMN2 | |
| SCHEMBL2172331 | 0.78 | S1PR1 (0.52) | S1PR1KLK7FNTAFNTBSMN1; SMN2 | |
| SCHEMBL2187665 | 0.78 | S1PR1 (0.55) | S1PR1KLK7FNTAFNTBMAPT | |
| SCHEMBL2171620 | 0.77 | ALDH1A1 (0.56) | S1PR1KLK7FNTAFNTBMAPT | |
| SCHEMBL2353028 | 0.74 | S1PR1 (0.45) | S1PR1KLK7FNTAFNTBL3MBTL1 | |
| SCHEMBL2352920 | 0.74 | S1PR1 (0.52) | S1PR1L3MBTL1MAPTLMNASCN9A | |
| SCHEMBL2171842 | 0.72 | ALDH1A1 (0.64) | MAPTHPGD | |
| SCHEMBL2171615 | 0.72 | ALDH1A1 (0.51) | S1PR1SMN1; SMN2LMNAHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |