Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KLK7 | P49862 | 3/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1371804 | 0.81 | S1PR1 (0.73) | S1PR1SCN9A | |
| SCHEMBL1371808 | 0.81 | S1PR1 (0.73) | S1PR1SCN9A | |
| SCHEMBL2187677 | 0.78 | SCN9A (0.48) | S1PR1SCN9A | |
| SCHEMBL2185456 | 0.78 | S1PR1 (0.52) | S1PR1HPGDMAPTKLK7FNTA | |
| SCHEMBL2171620 | 0.78 | ALDH1A1 (0.56) | S1PR1HPGDMAPTALDH1A1KLK7 | |
| SCHEMBL2357200 | 0.76 | S1PR1 (0.48) | S1PR1MAPTALDH1A1FNTAFNTB | |
| SCHEMBL2353028 | 0.75 | S1PR1 (0.45) | S1PR1MAPTALDH1A1KLK7FNTA | |
| SCHEMBL2172331 | 0.75 | S1PR1 (0.52) | S1PR1KLK7FNTAFNTBSMN1; SMN2 | |
| SCHEMBL2352920 | 0.75 | S1PR1 (0.52) | S1PR1HPGDMAPTALDH1A1LMNA | |
| SCHEMBL2171615 | 0.73 | ALDH1A1 (0.51) | S1PR1HPGDALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |