Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21855363 | 0.89 | ESR1 (0.51) | ESR1ESR2ADRB3 | |
| SCHEMBL21855306 | 0.88 | ESR1 (0.43) | ESR1ESR2THRBTHRAADRB3 | |
| SCHEMBL21855322 | 0.84 | ESR1 (0.51) | ESR1ESR2ADRB3 | |
| SCHEMBL21855360 | 0.79 | ESR1 (0.65) | ESR1ESR2MIFMAPTPDCD1 | |
| SCHEMBL21855347 | 0.78 | ESR1 (0.43) | ESR1ESR2ADRB3 | |
| SCHEMBL22468651 | 0.77 | AR (0.43) | — | |
| SCHEMBL21855388 | 0.76 | REN (0.36) | ESR1ESR2 | |
| SCHEMBL925617 | 0.75 | ESR1 (0.80) | ESR1ESR2MIFMAPTPDCD1 | |
| SCHEMBL21855320 | 0.74 | ESR1 (0.47) | ESR1ESR2ADRB3 | |
| SCHEMBL14498224 | 0.72 | ESR1 (0.74) | ESR1ESR2ADRB3MIFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081999-A1 | ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE | ESSA PHARMA, INC. (CA) | 2020-04-23 | — | — | WO | disclosed |