Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LATS1 | O95835 | 12/20 | 0.39 |
| ▸ | LATS2 | Q9NRM7 | 9/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17503745 | 0.84 | CYP2E1 (0.44) | ADORA2AADORA1CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL2188560 | 0.82 | ADORA1 (0.58) | ADORA2AADORA1 | |
| SCHEMBL2190316 | 0.74 | ADORA1 (0.53) | ADORA2AADORA1CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL21875480 | 0.71 | LATS1 (0.61) | LATS1LATS2 | |
| SCHEMBL2184224 | 0.71 | ADORA2A (0.47) | ADORA2AADORA1CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL2187983 | 0.71 | ADORA2A (0.56) | ADORA2AADORA1CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL15645485 | 0.70 | LATS1 (0.65) | MAPTLATS1LATS2 | |
| SCHEMBL18230128 | 0.69 | CYP2E1 (0.53) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL2186774 | 0.69 | ADORA2A (0.46) | ADORA2AADORA1CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL15644916 | 0.69 | LATS1 (0.50) | LATS1LATS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346859-A1 | HETEROCYCLIC JAK KINASE INHIBITORS | AstraZeneca AB (SE) | 2011-07-27 | — | — | EP | disclosed |