Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | LTK | P29376 | 2/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30095684 | 0.75 | PDE7A (0.41) | ADORA2AADORA1FYN | |
| SCHEMBL2188560 | 0.74 | ADORA1 (0.58) | ADORA2AADORA1CYP1A2 | |
| SCHEMBL20665484 | 0.72 | ADORA2A (0.63) | ADORA2AADORA1NTRK1NTRK2CLK4 | |
| SCHEMBL2190316 | 0.72 | ADORA1 (0.53) | ADORA2AADORA1LRRK2JAK2JAK3 | |
| SCHEMBL2184224 | 0.72 | ADORA2A (0.47) | ADORA2AADORA1NTRK1LRRK2AURKA | |
| SCHEMBL3301792 | 0.72 | ADORA2A (1.00) | ADORA2AADORA1 | |
| SCHEMBL2185605 | 0.71 | ADORA2A (0.46) | ADORA2AADORA1LRRK2JAK2JAK3 | |
| SCHEMBL27637072 | 0.69 | ADORA2A (0.61) | ADORA2AADORA1NTRK1NTRK2CLK4 | |
| SCHEMBL2191285 | 0.69 | ADORA1 (0.47) | ADORA2AADORA1LRRK2FGFR1KDR | |
| SCHEMBL2368763 | 0.68 | ADORA2A (1.00) | ADORA2AADORA1NTRK1NTRK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346859-A1 | HETEROCYCLIC JAK KINASE INHIBITORS | AstraZeneca AB (SE) | 2011-07-27 | — | — | EP | disclosed |