Sugi Predict

Sugi Predict / Compounds / SCHEMBL21856239

SCHEMBL21856239

SCHEMBL21856239

CC(C)(C)OC(=O)N1CCC(C)(C(=O)c2cccnc2Cl)CC1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.69
▸ GPR119 Q8TDV5 4/20 0.45
▸ OPRD1 P41143 1/20 0.45
▸ OPRK1 P41145 1/20 0.45
▸ DTYMK P23919 1/20 0.42
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ NAMPT P43490 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ JAK2 O60674 1/20 0.40
▸ JAK1 P23458 1/20 0.40
▸ GRM5 P41594 1/20 0.39
▸ FNTA P49354 1/20 0.39
▸ FNTB P49356 1/20 0.39
▸ USP30 Q70CQ3 1/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ ATM Q13315 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27061355 0.86 POLB (0.54) POLBGPR119OPRD1OPRK1DTYMK
SCHEMBL21855902 0.83 LMNA (0.49) POLBCYP2C19LMNASMN1; SMN2
SCHEMBL12832991 0.82 POLB (1.00) POLBGPR119DTYMKMEN1KMT2A
SCHEMBL21855998 0.80 POLB (0.47) POLBGPR119OPRD1OPRK1MEN1
SCHEMBL21855908 0.80 POLB (0.47) POLBGPR119OPRD1OPRK1NAMPT
SCHEMBL20510089 0.80 POLB (0.46) POLBGPR119OPRD1OPRK1MEN1
SCHEMBL28695801 0.79 POLB (0.58) POLBGPR119OPRD1OPRK1DTYMK
SCHEMBL22499445 0.78 POLB (0.57) POLBGPR119OPRD1OPRK1DTYMK
SCHEMBL21856177 0.78 POLB (0.57) POLBGPR119OPRD1OPRK1DTYMK
SCHEMBL29506059 0.78 POLB (0.57) POLBGPR119OPRD1OPRK1DTYMK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250066357-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2025-02-27 — — US disclosed
US-12209074-B2 SHP2 phosphatase allosteric inhibitor BEIJING SHENOGEN PHARMA GROUP LTD. (CN) 2025-01-28 — — US disclosed
US-12187721-B2 Protein tyrosine phosphatase inhibitors ARRAY BIOPHARMA INC. (US) 2025-01-07 — — US disclosed
US-20240124453-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2024-04-18 — — US disclosed
US-11884664-B2 Protein tyrosine phosphatase inhibitors ARRAY BIOPHARMA INC. (US) 2024-01-30 — — US disclosed
EP-3867238-B1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC (US) 2023-06-07 — — EP disclosed
US-11634417-B2 Protein tyrosine phosphatase inhibitors ARRAY BIOPHARMA INC. (US) 2023-04-25 — — US disclosed
US-20220388977-A1 SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR BEIJING SHENOGEN PHARMA GROUP LTD. (CN) 2022-12-08 — — US disclosed
US-20220388977-A1 SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR BEIJING SHENOGEN PHARMA GROUP LTD. (CN) 2022-12-08 — — US disclosed
US-20220251083-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2022-08-11 — — US disclosed
EP-3984999-A1 SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR Beijing Shenogen Pharma Group Ltd. (CN) 2022-04-20 — — EP disclosed
EP-3984999-A1 SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR Beijing Shenogen Pharma Group Ltd. (CN) 2022-04-20 — — EP disclosed
CN-114008035-A SHP2 phosphatase allosteric inhibitor 北京盛诺基医药科技股份有限公司 2022-02-01 — — CN disclosed
US-20210380582-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2021-12-09 — — US disclosed
WO-2020249079-A1 SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR 北京盛诺基医药科技股份有限公司 2020-12-17 — — WO disclosed
US-20200317665-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2020-10-08 — — US disclosed
WO-2020081848-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2020-04-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250066357-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS PPM1A, PPM1F, PPP5C POLB 2558/4885GPR119 2596/4885OPRD1 4634/4885
US-11884664-B2 Protein tyrosine phosphatase inhibitors PPM1A, PPM1F, PPP5C POLB 2681/4885GPR119 2598/4885OPRD1 4663/4885
US-12187721-B2 Protein tyrosine phosphatase inhibitors PPM1A, PTP4A1, PPP5C POLB 2528/4885GPR119 2614/4885OPRD1 4683/4885
US-20200317665-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS PPM1A, PPM1F, PPP5C POLB 2681/4885GPR119 2598/4885OPRD1 4663/4885
US-20210380582-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS PPM1A, PTP4A1, PPP5C POLB 2528/4885GPR119 2614/4885OPRD1 4683/4885
US-20220388977-A1 SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR PTPN1, PTPN5, PTPN18 POLB 4589/4885GPR119 595/4885OPRD1 3856/4885
US-20240124453-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS PPM1A, PPM1F, PPP5C POLB 2681/4885GPR119 2598/4885OPRD1 4663/4885
US-11634417-B2 Protein tyrosine phosphatase inhibitors PPM1A, PPM1F, PPP5C POLB 2681/4885GPR119 2598/4885OPRD1 4663/4885
US-12209074-B2 SHP2 phosphatase allosteric inhibitor PTPN1, PTPN5, PTPN18 POLB 4589/4885GPR119 595/4885OPRD1 3856/4885
US-20220251083-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS PPM1A, PPM1F, PPP5C POLB 2681/4885GPR119 2598/4885OPRD1 4663/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.