Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | TTR | P02766 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12884286 | 0.87 | GRM5 (0.65) | GRM5KCNH2TTRCYP1A2NPC1 | |
| SCHEMBL5778843 | 0.85 | GRM5 (0.62) | GRM5KCNH2TTRCYP1A2NPC1 | |
| SCHEMBL15422868 | 0.79 | TTR (0.68) | GRM5KCNH2TTRCYP1A2NPC1 | |
| SCHEMBL484570 | 0.79 | GRM5 (0.56) | GRM5KCNH2TTRCYP1A2NPC1 | |
| SCHEMBL12884290 | 0.79 | TTR (0.62) | GRM5KCNH2TTRCYP1A2ALDH1A1 | |
| SCHEMBL15877543 | 0.76 | GRM5 (0.56) | GRM5KCNH2TTRNCF1NOS2 | |
| SCHEMBL21858048 | 0.75 | GRM5 (0.54) | GRM5KCNH2TTRCYP1A2NPC1 | |
| SCHEMBL15877631 | 0.74 | GRM5 (0.62) | GRM5KCNH2TTRCYP1A2KDM4E | |
| SCHEMBL15877809 | 0.73 | GRM5 (0.59) | GRM5KCNH2TTRCYP1A2CYP3A4 | |
| SCHEMBL2808633 | 0.72 | TTR (0.55) | GRM5KCNH2TTRCYP1A2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112955422-B | polycyclic compound | 三菱瓦斯化学株式会社 | 2023-08-22 | — | — | CN | claimed |
| US-20210355058-A1 | POLYCYCLIC COMPOUNDS | MITSUBISHI GAS CHEMICAL CO (JP) | 2021-11-18 | — | — | US | claimed |
| US-20210340317-A1 | POLYCYCLIC COMPOUNDS | REUTER CHEMISCHE APPARATEBAU E.K. (DE) | 2021-11-04 | — | — | US | claimed |
| CN-112955422-A | Polycyclic compounds | 三菱瓦斯化学株式会社 | 2021-06-11 | — | — | CN | claimed |
| WO-2020079225-A1 | POLYCYCLIC COMPOUNDS | REUTER CHEMISCHE APPARATEBAU E.K. (DE) | 2020-04-23 | — | — | WO | claimed |
| WO-2020080558-A1 | POLYCYCLIC COMPOUNDS | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2020-04-23 | — | — | WO | claimed |
| CN-112955422-B | polycyclic compound | 三菱瓦斯化学株式会社 | 2023-08-22 | — | — | CN | disclosed |
| US-20210355058-A1 | POLYCYCLIC COMPOUNDS | MITSUBISHI GAS CHEMICAL CO (JP) | 2021-11-18 | — | — | US | disclosed |
| US-20210340317-A1 | POLYCYCLIC COMPOUNDS | REUTER CHEMISCHE APPARATEBAU E.K. (DE) | 2021-11-04 | — | — | US | disclosed |
| CN-112955422-A | Polycyclic compounds | 三菱瓦斯化学株式会社 | 2021-06-11 | — | — | CN | disclosed |
| WO-2020079225-A1 | POLYCYCLIC COMPOUNDS | REUTER CHEMISCHE APPARATEBAU E.K. (DE) | 2020-04-23 | — | — | WO | disclosed |
| WO-2020080558-A1 | POLYCYCLIC COMPOUNDS | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2020-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210340317-A1 | POLYCYCLIC COMPOUNDS | CBR1, C1R, CBR3 | GRM5 2617/4885KCNH2 893/4885TTR 2209/4885 |
| US-20210355058-A1 | POLYCYCLIC COMPOUNDS | CBR1, CBR3, C1R | GRM5 2703/4885KCNH2 1032/4885TTR 1772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.