Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.52 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2616321 | 0.84 | HSD17B10 (0.60) | DRD4DRD3ALDH1A1MEN1GAA | |
| SCHEMBL2616306 | 0.79 | HSD17B10 (0.55) | DRD4HTR2CHTR2BDRD3ALDH1A1 | |
| SCHEMBL17809643 | 0.76 | CHRNA7 (0.46) | CYP11B1CYP11B2ALDH1A1MEN1GAA | |
| SCHEMBL17809552 | 0.76 | USP30 (0.47) | CYP11B1CYP11B2ALDH1A1MEN1GAA | |
| SCHEMBL17809579 | 0.75 | CYP11B1 (0.62) | CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL24316050 | 0.74 | DRD1 (0.55) | DRD4HTR2CHTR2BDRD3ALDH1A1 | |
| SCHEMBL2625807 | 0.74 | NOTUM (0.59) | DRD4HTR2CHTR2BDRD3MEN1 | |
| SCHEMBL17809574 | 0.74 | ALDH1A1 (0.51) | CYP11B1CYP11B2ALDH1A1MEN1GAA | |
| SCHEMBL17809611 | 0.72 | MEN1 (0.50) | CYP11B1CYP11B2ALDH1A1MEN1GAA | |
| SCHEMBL28281659 | 0.72 | CYP11B2 (0.51) | CYP11B1CYP11B2HSD17B3HTR2CWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020068304-A2 | INHIBITORS OF RNA-GUIDED NUCLEASE TARGET BINDING AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2020-04-02 | — | — | WO | disclosed |