Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19064107 | 0.87 | ALDH1A1 (0.37) | PIN1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL15881241 | 0.81 | SMN1; SMN2 (0.41) | PIN1ALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL15173489 | 0.80 | PRKCQ (0.38) | PIN1ALDH1A1TSHR | |
| SCHEMBL27712693 | 0.80 | CYP1A2 (0.38) | PIN1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL4402867 | 0.78 | CYP1A2 (0.38) | PIN1MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4402873 | 0.78 | CYP1A2 (0.38) | PIN1MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2185792 | 0.77 | VCAM1 (0.36) | PIN1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL8656469 | 0.76 | HPGD (0.49) | PIN1ALDH1A1MAPTTDP1L3MBTL1 | |
| SCHEMBL26548248 | 0.75 | TSHR (0.41) | PIN1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL1982550 | 0.75 | ALDH1A1 (0.44) | ALDH1A1MEN1MAPTKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023067546-A1 | NOVEL BICYCLIC HETEROARYL DERIVATIVES AS SOS1:KRAS PROTEINPROTEIN INTERACTION INHIBITORS | SATYARX PHARMA INNOVATIONS PVT LTD (IN) | 2023-04-27 | — | — | WO | disclosed |
| EP-2342190-A1 | BICYCLIC KINASE INHIBITORS | Novartis AG (CH) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010026121-A1 | BICYCLIC KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |