Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28310921 | 0.85 | GABRA1 (0.38) | KCNK3KCNK9NPSR1RXFP1MCHR1 | |
| SCHEMBL16959519 | 0.84 | KCNK3 (0.36) | KCNK3KCNK9NPSR1RXFP1MCHR1 | |
| SCHEMBL2186854 | 0.81 | MAPT (0.40) | NPSR1MEN1KMT2ACA1CA2 | |
| SCHEMBL3155854 | 0.77 | SLC6A2 (0.43) | NPSR1IRAK4SLC6A2SLC6A4KCNH2 | |
| SCHEMBL16953645 | 0.76 | KCNK3 (0.37) | KCNK3KCNK9NPSR1RXFP1MCHR1 | |
| SCHEMBL16953643 | 0.75 | KCNK3 (0.36) | KCNK3KCNK9NPSR1RXFP1MCHR1 | |
| SCHEMBL16958983 | 0.71 | ALDH1A1 (0.35) | KCNK3KCNK9NPSR1RXFP1MCHR1 | |
| SCHEMBL11397648 | 0.71 | ERN1 (0.40) | KCNK3KCNK9NPSR1RXFP1MCHR1 | |
| SCHEMBL16959516 | 0.71 | CA1 (0.38) | KCNK3KCNK9RXFP1MCHR1IRAK4 | |
| SCHEMBL16958979 | 0.71 | KCNK3 (0.34) | KCNK3KCNK9NPSR1RXFP1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342205-A1 | SUBSTITUTED TRICYCLIC ACID DERIVATIVES AS S1P1 RECEPTOR AGONISTS USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | Arena Pharmaceuticals, Inc. (US) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010027431-A1 | SUBSTITUTED TRICYCLIC ACID DERIVATIVES AS S1P1 RECEPTOR AGONISTS USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2010-03-11 | — | — | WO | disclosed |