SCHEMBL2186187

SCHEMBL2186187

CCCc1nc2ccccc2c2ccccc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.60
KMT2A Q03164 2/20 0.60
ALDH1A1 P00352 2/20 0.60
GAA P10253 1/20 0.60
HPGD P15428 1/20 0.60
GPR3 P46089 1/20 0.50
PDE4A P27815 2/20 0.49
PDE4B Q07343 2/20 0.49
PDE4C Q08493 2/20 0.49
PDE4D Q08499 2/20 0.49
ELANE P08246 1/20 0.49
LCK P06239 1/20 0.45
TLR8 Q9NR97 2/20 0.43
HSP90AB1 P08238 1/20 0.43
MAPK1 P28482 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TLR7 Q9NYK1 1/20 0.43
POLB P06746 1/20 0.42
RAD52 P43351 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29539238 0.89 KMT2A (0.56) KDM4EKMT2AALDH1A1GAAHPGD
SCHEMBL1415347 0.87 KMT2A (0.55) KDM4EKMT2AALDH1A1GAAHPGD
SCHEMBL29099832 0.85 KMT2A (0.53) KDM4EKMT2AALDH1A1GAAHPGD
SCHEMBL29099831 0.84 KDM4E (0.47) KDM4EKMT2AALDH1A1GAAHPGD
SCHEMBL12533981 0.83 KMT2A (0.64) KDM4EKMT2AALDH1A1GAAHPGD
SCHEMBL29099859 0.83 KDM4E (0.46) KDM4EKMT2AALDH1A1GAAHPGD
SCHEMBL29099825 0.83 ADORA3 (0.42) KDM4EKMT2AALDH1A1GAAHPGD
SCHEMBL29099807 0.81 KMT2A (0.45) KDM4EKMT2AALDH1A1GAAHPGD
SCHEMBL29099818 0.81 USP2 (0.48) KDM4EKMT2AALDH1A1GAAHPGD
SCHEMBL7067981 0.81 KDM4E (0.56) KDM4EKMT2AALDH1A1GAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116969889-B Preparation method of phenanthridine or chiral phenanthridine compound 瑞博(杭州)医药科技有限公司 2024-03-26 CN disclosed
CN-116969889-A Preparation method of phenanthridine or chiral phenanthridine compound 瑞博(杭州)医药科技有限公司 2023-10-31 CN disclosed
WO-2023182835-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME 솔루스첨단소재 주식회사 2023-09-28 WO disclosed
EP-1831167-B1 LIQUID PHASE PROCESS FOR THE SYNTHESIS OF ANNULATED PYRIDINES OVER ZEOLITE TYPE MOLECULAR SIEVE CATALYSTS COUNCIL SCIENT IND RES (IN) 2011-07-13 EP disclosed
US-7491828-B2 Liquid phase process for the synthesis of annulated pyridines over molecular sieve catalysts COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2009-02-17 US disclosed
EP-1831167-A1 LIQUID PHASE PROCESS FOR THE SYNTHESIS OF ANNULATED PYRIDINES OVER ZEOLITE TYPE MOLECULAR SIEVE CATALYSTS Council of Scientific and Industrial Research (IN) 2007-09-12 EP disclosed
US-20060149068-A1 Liquid phase process for the synthesis of annulated pyridines over molecular sieve catalysts COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2006-07-06 US disclosed
WO-2006070403-A1 LIQUID PHASE PROCESS FOR THE SYNTHESIS OF ANNULATED PYRIDINES OVER ZEOLITE TYPE MOLECULAR SIEVE CATALYSTS COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2006-07-06 WO disclosed
EP-0045171-B1 9-AMINO-1-HYDROXYOCTAHYDROBENZO(C)QUINOLINES AND DERIVATIVES THEREOF PFIZER INC. (US) 1985-02-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060149068-A1 Liquid phase process for the synthesis of annulated pyridines over molecular sieve catalysts AURKA, CDK4, SKP2 KDM4E 526/4885KMT2A 1064/4885ALDH1A1 255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.